Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Klobassa, DS; Zoehrer, B; Paulke-Korinek, M; Gruber-Sedlmayr, U; Pfurtscheller, K; Strenger, V; Sonnleitner, A; Kerbl, R; Ausserer, B; Arocker, W; Kaulfersch, W; Hausberger, B; Covi, B; Eitelberger, F; Vécsei, A; Simma, B; Birnbacher, R; Kurz, H; Zwiauer, K; Weghuber, D; Heuberger, S; Quehenberger, F; Kollaritsch, H; Zenz, W.
The burden of pneumococcal meningitis in Austrian children between 2001 and 2008.
Eur J Pediatr. 2014; 173(7):871-878
Doi: 10.1007/s00431-013-2260-8
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kohlfürst Daniela
- Zenz Werner
- Co-Autor*innen der Med Uni Graz
- Gruber-Sedlmayr Ursula
- Pfurtscheller Klaus
- Quehenberger Franz
- Sonnleitner Astrid
- Strenger Volker
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- Abstract:
- The present study was conducted to evaluate the burden of pneumococcal meningitis in Austrian children between 2001 and 2008. Clinical outcome was retrospectively analyzed both on discharge and on follow-up investigations. This study was based on a prospective multicentre surveillance study on hospitalized invasive pneumococcal infections in Austrian children with a total annual "study population" of about 399,000 children aged below 5 years per year. Between 2001 and 2008, 74 cases of pneumococcal meningitis were identified in children aged below 5 years. The mean annual incidence rate for pneumococcal meningitis was 2.3 per 100,000 children in this age group. In 57/74 children (mean age on admission 14.5 ± 13.3 months), outcome data on hospital discharge were available: 5 deaths (8.8%), 20 children (35.1%) with sequelae and 32 children (56.1%) without sequelae were observed. Sequelae on discharge included motor impairment in 8 children (14.0%), hearing impairment in 9 children (15.8%) and/or other complications in 14 children (24.6%). In 7/8 children with motor deficits, matching cerebral lesions were identified by neuroimaging: cerebral infarction in five children, cerebral vasculitis and cerebral abscess in one child each. In 40/57 children, long-term outcome (18.9 ± 20.2 months after discharge) could be assessed: 1 child (2.5%) died 9 months after hospital discharge, 11 children (27.5%) had one or two long-term sequelae and 28 children (70.0%) had no sequelae. Long-term sequelae included motor impairment in three children (7.5%), hearing impairment in nine children (22.5%) and other deficits in two children (5.0%). Our study confirms that pneumococcal meningitis causes high mortality and severe long-term sequelae. On long-term follow-up, we observed improvements of motor impairment, but not of hearing impairment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adolescent - epidemiology
- Child -
- Child, Preschool -
- Female -
- Follow-Up Studies -
- Hospitalization -
- Humans -
- Incidence -
- Infant -
- Male -
- Meningitis, Pneumococcal - epidemiology Meningitis, Pneumococcal - microbiology Meningitis, Pneumococcal - mortality
- Prognosis -
- Prospective Studies -
- Retrospective Studies -
- Streptococcus pneumoniae - isolation & purification
- Find related publications in this database (Keywords)
- Bacterial meningitis
- Streptococcus pneumoniae
- Pneumococcal disease
- Children
- Long-term outcome
- Long-term sequelae