Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Spilka, R; Ernst, C; Mehta, AK; Haybaeck, J.
Eukaryotic translation initiation factors in cancer development and progression.
Cancer Lett. 2013; 340(1):9-21
Doi: 10.1016/j.canlet.2013.06.019
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
- Co-Autor*innen der Med Uni Graz
- Ernst Christina
- Mehta Anita Kuldeep
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- Abstract:
- Eukaryotic gene expression is a complicated process primarily regulated at the levels of gene transcription and mRNA translation. The latter involves four main steps: initiation, elongation, termination and recycling. Translation regulation is primarily achieved during initiation which is orchestrated by 12 currently known eukaryotic initiation factors (eIFs). Here, we review the current state of eIF research and present a concise summary of the various eIF subunits. As eIFs turned out to be critically implicated in different oncogenic processes the various eIF members and their contribution to onset and progression of cancer are featured.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Carcinogenesis - metabolism
- Disease Progression -
- Eukaryotic Initiation Factors - physiology
- Gene Expression Regulation, Neoplastic -
- Humans -
- Neoplasms - genetics
- Protein Biosynthesis -
- Protein Processing, Post-Translational -
- Find related publications in this database (Keywords)
- Eukaryotic initiation factors
- Translation initiation
- Cancer