Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pludowski, P; Holick, MF; Pilz, S; Wagner, CL; Hollis, BW; Grant, WB; Shoenfeld, Y; Lerchbaum, E; Llewellyn, DJ; Kienreich, K; Soni, M.
Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence.
Autoimmun Rev. 2013; 12(10):976-989
Doi: 10.1016/j.autrev.2013.02.004
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kienreich Katharina
- Lerchbaum Elisabeth
- Pilz Stefan
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- Abstract:
- Background: Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being. Vitamin D deficiency and insufficiency as a global health problem are likely to be a risk for wide spectrum of acute and chronic illnesses. Methods: A review of randomized controlled trials, meta-analyses, and other evidence of vitamin D action on various health outcomes. Results: Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality. Conclusions: Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. Supplementation guidance and population strategies for the eradication of vitamin D deficiency must be included in the priorities of physicians, medical professionals and healthcare policy-makers. (c) 2013 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium - therapeutic use
- Dietary Supplements -
- Female -
- Humans -
- Pregnancy -
- Vitamin D - adverse effects
- Vitamin D Deficiency - complications
- Vitamins - adverse effects
- World Health -
- Find related publications in this database (Keywords)
- Vitamin D
- 25(OH)D level
- Falls
- Fractures
- Cardiovascular
- Cancer
- Immunity
- Autoimmunity
- Fertility
- Pregnancy
- Infancy
- Infections
- Mortality
- Dementia