Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schips, L; Zigeuner, R; Ratschek, M; Rehak, P; Rüschoff, J; Langner, C.
Analysis of insulin-like growth factors and insulin-like growth factor I receptor expression in renal cell carcinoma.
AMER J CLIN PATHOL. 2004; 122(6): 931-937.
Doi: 10.1309/G7PY-0RE7-T86H-HQYV
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Schips Luigi
- Co-Autor*innen der Med Uni Graz
- Ratschek Manfred
- Rehak Peter
- Zigeuner Richard
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- Abstract:
- The expression of insulin-like growth factors I (IGF-I) and II (IGF-II) and insulin-like growth factor-I receptor (IGF-IR) was studied in 137 clear cell, 23 chromophobe, and 20 papillary renal cell carcinomas (RCCs) using a tissue microarray technique. IGF-I immunoreactivity was detected in 110 (82.1%) of 134 clear cell, 8 (36%) of 22 chromophobe, and 3 (15%) of 20 papillary RCCs (P < .001). IGF-IR immunoreactivity was detected in 39 (29.5%) of 132 clear cell, 9 (41%) of 22 chromophobe, and 19 (95%) of 20 papillary RCCs (P < .001). In contrast, all tumors lacked IGF-II expression. Expression of IGF-I and IGF-IR was not related to tumor stage, grade, or prognosis. The IGF system is expressed differentially among different tumor types. The expression of IGF-I together with its receptor, IGF-IR, provides evidence for the existence of an autocrine-paracrine loop of tumor cell stimulation in RCC and makes this type of cancer a candidate for therapeutic strategies aimed to interfere with the IGF pathway.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Carcinoma, Renal Cell - metabolism
- Female - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Kidney Neoplasms - metabolism
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- Find related publications in this database (Keywords)
- insulin-like growth factors
- IGF-I
- IGF-II
- insulin-like growth factor I receptor
- IGF-IR
- renal cell carcinoma
- histologic subtype
- immunohistochemistry