Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mbisa, JL; Hue, S; Buckton, AJ; Myers, RE; Duiculescu, D; Ene, L; Oprea, C; Tardei, G; Rugina, S; Mardarescu, M; Floch, C; Notheis, G; Zohrer, B; Cane, PA; Pillay, D; .
Phylodynamic and Phylogeographic Patterns of the HIV Type 1 Subtype F1 Parenteral Epidemic in Romania.
AIDS Res Hum Retroviruses. 2012; 28(9):1161-1166
Doi: 10.1089/AID.2011.0390
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Zöhrer Bettina
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In the late 1980s an HIV-1 epidemic emerged in Romania that was dominated by subtype F1. The main route of infection is believed to be parenteral transmission in children. We sequenced partial pol coding regions of 70 subtype F1 samples from children and adolescents from the PENTA-EPPICC network of which 67 were from Romania. Phylogenetic reconstruction using the sequences and other publically available global subtype F sequences showed that 79% of Romanian F1 sequences formed a statistically robust monophyletic cluster. The monophyletic cluster was epidemiologically linked to parenteral transmission in children. Coalescent-based analysis dated the origins of the parenteral epidemic to 1983 [1981-1987; 95% HPD]. The analysis also shows that the epidemic's effective population size has remained fairly constant since the early 1990s suggesting limited onward spread of the virus within the population. Furthermore, phylogeographic analysis suggests that the root location of the parenteral epidemic was Bucharest.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Amino Acid Sequence -
- Child -
- Drug Resistance, Viral -
- Female -
- Genetic Variation -
- HIV Seropositivity - epidemiology
- HIV-1 - genetics
- Humans -
- Infectious Disease Transmission, Vertical - statistics and numerical data
- Male -
- Markov Chains -
- Molecular Sequence Data -
- Phylogeny -
- Phylogeography -
- Prevalence -
- Prevalence - epidemiology
- pol Gene Products, Human Immunodeficiency Virus - genetics