Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lu, X; Wang, L; Chen, S; He, L; Yang, X; Shi, Y; Cheng, J; Zhang, L; Gu, CC; Huang, J; Wu, T; Ma, Y; Li, J; Cao, J; Chen, J; Ge, D; Fan, Z; Li, Y; Zhao, L; Li, H; Zhou, X; Chen, L; Liu, D; Chen, J; Duan, X; Hao, Y; Wang, L; Lu, F; Liu, Z; Yao, C; Shen, C; Pu, X; Yu, L; Fang, X; Xu, L; Mu, J; Wu, X; Zheng, R; Wu, N; Zhao, Q; Li, Y; Liu, X; Wang, M; Yu, D; Hu, D; Ji, X; Guo, D; Sun, D; Wang, Q; Yang, Y; Liu, F; Mao, Q; Liang, X; Ji, J; Chen, P; Mo, X; Li, D; Chai, G; Tang, Y; Li, X; Du, Z; Liu, X; Dou, C; Yang, Z; Meng, Q; Wang, D; Wang, R; Yang, J; Schunkert, H; Samani, NJ; Kathiresan, S; Reilly, MP; Erdmann, J; Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium; Peng, X; Wu, X; Liu, D; Yang, Y; Chen, R; Qiang, B; Gu, D.
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
Nat Genet. 2012; 44(8):890-894
Doi: 10.1038/ng.2337
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- Study Group Mitglieder der Med Uni Graz:
- Dobnig Harald
- März Winfried
- Meinitzer Andreas
- Pilz Stefan
- Renner Wilfried
- Scharnagl Hubert
- Stojakovic Tatjana
- Tomaschitz Andreas
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- Abstract:
- We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
- Find related publications in this database (using NLM MeSH Indexing)
- Asian Continental Ancestry Group - genetics
- Case-Control Studies -
- Case-Control Studies -
- Chromosome Mapping -
- Coronary Artery Disease - genetics
- European Continental Ancestry Group - genetics
- Genetic Predisposition to Disease -
- Genome-Wide Association Study -
- Guanylate Cyclase - genetics
- Humans -
- Linkage Disequilibrium -
- Membrane Glycoproteins - genetics
- Plasma Membrane Calcium-Transporting ATPases - genetics
- Polymorphism, Single Nucleotide -
- Proteins - genetics
- Receptors, Cytoplasmic and Nuclear - genetics