Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Juch, H; Blaschitz, A; Dohr, G; Hutter, H.
HLA class I expression in the human placenta.
Wien Med Wochenschr. 2012; 162(9-10):196-200
Doi: 10.1007/s10354-012-0070-7
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hutter Heinz
- Juch Herbert
- Co-Autor*innen der Med Uni Graz
- Blaschitz Astrid
- Dohr Gottfried
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- Abstract:
- Placental trophoblast cells of the semi-allogenic human conceptus invade deeply into maternal uterine tissue. From a classical immunoiogic point of view this invasion and the following growth and development of the fetus in the uterus have to be tolerated by a pregnant woman's immune system. Among the various possible protective mechanisms that may be involved, the unique expression pattern of HLA class I molecules seems to be relevant. Besides many other differences between placentation and organ transplantation, this extraordinary HLA class I expression on trophoblast explains why pregnancy should not be considered an immunologic paradox but rather a fascinating example of a very special challenge for the female immune system.
- Find related publications in this database (using NLM MeSH Indexing)
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- Antigen-Presenting Cells - immunology
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- Female - administration & dosage
- Fetal Development - immunology
- Histocompatibility Antigens Class I - blood
- Humans - administration & dosage
- Immune Tolerance - immunology
- Infant, Newborn - administration & dosage
- Killer Cells, Natural - immunology
- Maternal-Fetal Exchange - immunology
- Placenta - immunology
- Pre-Eclampsia - immunology
- Pregnancy - administration & dosage
- Pregnancy Trimester, First - immunology
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- Trophoblasts - immunology