Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Falkensammer, J; Gasteiger, S; Stojakovic, T; Stühlinger, M; Scharnagl, H; Frech, A; Fraedrich, G; Greiner, A; Huber, K.
Elevated baseline hs-cTnT levels predict exercise-induced myocardial ischemia in patients with peripheral arterial disease.
Clin Chim Acta. 2012; 413(19-20):1678-1682
Doi: 10.1016/j.cca.2012.05.014
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- Introduction: Due to the systemic nature of atherosclerosis, the prevalence of coronary artery disease (CAD) is high in patients with peripheral arterial disease (PAD). A biochemical assay for assessing cardiac risk might improve clinical evaluation of PAD patients. The aim of this study was to investigate whether a new high-sensitivity cardiac Troponin T (hs-cTnT) assay can predict exercise-induced myocardial ischemia in PAD patients without clinical signs of CAD. Methods: Sixty-eight ambulatory patients with Fontaine stage II PAD underwent treadmill stress testing to maximum walking distance. Myocardial ischemia was assessed using a 2-lead Holter ECG and ST-segment depression of >= 0.2 mV was considered significant. Hs-cTnT was measured from serum samples taken at baseline as well as 5, 10 and 30 min after exercise. Results: Hs-cTnT baseline levels were significantly higher (193 ng/L (5.0; 20.2 ng/L) vs. 6.6 ng/L (4.4; 9.4 ng/L); p = 0.037) and increase of serum levels 5 min after cessation of exercise was more pronounced (1.09 ng/L (0.23; 1.80 ng/L) vs. 0.22 ng/L (-0.1; 0.65 ng/L), p = 0.032) in ECG positive patients compared to individuals with normal ECG. Logistic regression analysis identified the baseline hs-cTnT serum level as an independent risk factor for developing significant exercise-induced ST-segment depression (odds ratio 1.2 per 1-unit increase, p = 0.015). Conclusions: In patients with PAD, exercise-induced myocardial ischemia is associated with elevated baseline levels and a significant early increase of hs-cTnT serum levels. (C) 2012 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biological Markers - blood
- Electrocardiography -
- Exercise -
- Exercise Test -
- Humans -
- Male -
- Middle Aged -
- Myocardial Ischemia - blood Myocardial Ischemia - complications Myocardial Ischemia - diagnosis
- Peripheral Arterial Disease - blood Peripheral Arterial Disease - complications Peripheral Arterial Disease - diagnosis
- Predictive Value of Tests -
- Risk Assessment -
- Risk Factors -
- Severity of Illness Index -
- Troponin T - blood
- Find related publications in this database (Keywords)
- Peripheral arterial disease
- Coronary artery disease
- Myocardial ischemia
- Exercise test
- Troponin