Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zittermann, A; Börgermann, J; Gummert, JF; Pilz, S.
Future directions in vitamin D and cardiovascular research.
Nutr Metab Cardiovasc Dis. 2012; 22(7):541-546
Doi: 10.1016/j.numecd.2012.02.004
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pilz Stefan
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- Abstract:
- Aims: Evidence is accumulating that vitamin D status may influence the risk of cardiovascular disease (CVD). Final confirmation for a causal relationship between vitamin D and CVD is however still lacking. The present viewpoint article outlines several future research directions to close this gap. Data synthesis: Future directions include the need of performing large randomised controlled supplementation trials with vitamin D in specific risk groups. In addition, large register sets of data on vitamin D supplementation can be used, provided that adequate statistical methods such as propensity score modelled analysis are applied. To better understand vitamin D-mediated effects on CVD risk, the routine measurement of circulating levels of the hormonal vitamin D form, 1,25-dihydroxyvitamin D, is also necessary, in addition to the determination of its precursor 25-hydroxyvitamin D. Further, genetic association studies may help in clarifying the contribution of vitamin D to the development of CVD. Finally, the interrelationship of vitamin D with physical activity should be considered when studying CVD risk. Conclusions: Overall, it can be expected that the next 10-15 years will provide an increased clarity concerning the role of vitamin D in CVD. (C) 2012 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology
- Dietary Supplements -
- Genetic Association Studies - trends
- Humans -
- Motor Activity -
- Risk Factors -
- Vitamin D - administration and dosage
- Vitamin D Deficiency - complications Vitamin D Deficiency - genetics Vitamin D Deficiency - physiopathology
- Find related publications in this database (Keywords)
- Vitamin D
- Cardiovascular disease
- Hypercalcaemia
- 25-Hydroxyvitamin D,1,25-dihydroxyvitamin D
- Gene polymorphisms
- Physical activity