Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Suhre, K; Shin, SY; Petersen, AK; Mohney, RP; Meredith, D; Wägele, B; Altmaier, E; CARDIoGRAM; Deloukas, P; Erdmann, J; Grundberg, E; Hammond, CJ; de Angelis, MH; Kastenmüller, G; Köttgen, A; Kronenberg, F; Mangino, M; Meisinger, C; Meitinger, T; Mewes, HW; Milburn, MV; Prehn, C; Raffler, J; Ried, JS; Römisch-Margl, W; Samani, NJ; Small, KS; Wichmann, HE; Zhai, G; Illig, T; Spector, TD; Adamski, J; Soranzo, N; Gieger, C; Assimes, TL; Deloukas, P; Erdmann, J; Holm, H; Kathiresan, S; König, IR; McPherson, R; Reilly, MP; Roberts, R; Samani, NJ; Schunkert, H; Stewart, AF.
Human metabolic individuality in biomedical and pharmaceutical research.
Nature. 2011; 477(7362):54-60
Doi: 10.1038/nature10354
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Mitglieder der Med Uni Graz:
- Dobnig Harald
- März Winfried
- Meinitzer Andreas
- Pilz Stefan
- Renner Wilfried
- Scharnagl Hubert
- Stojakovic Tatjana
- Tomaschitz Andreas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences in metabolite levels per allele copy. Our associations provide new functional insights for many disease-related associations that have been reported in previous studies, including those for cardiovascular and kidney disorders, type 2 diabetes, cancer, gout, venous thromboembolism and Crohn's disease. The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biomedical Research -
- Blood - metabolism
- Child -
- Chronic Disease -
- Coronary Artery Disease - genetics
- Diabetes Mellitus - genetics
- Drug Industry -
- Female -
- Genetic Loci - genetics
- Genetic Variation -
- Genome-Wide Association Study -
- Genotype -
- Humans -
- Male -
- Metabolism - genetics
- Metabolomics -
- Middle Aged -
- Pharmacogenetics -
- Renal Insufficiency - genetics
- Risk Factors -
- Venous Thromboembolism - genetics
- Young Adult -