Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zinke-Cerwenka, W; Valentin, A; Posch, U; Beham-Schmid, C; Groselj-Strele, A; Linkesch, W; Wölfler, A; Sill, H.
Reduced-intensity allografting in patients with therapy-related myeloid neoplasms and active primary malignancies.
Bone Marrow Transplant. 2011; 46(12):1540-1544
Doi: 10.1038/bmt.2011.165
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sill Heinz
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Groselj-Strele Andrea
- Linkesch Werner
- Posch Ursula
- Wölfler Albert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Therapy-related myeloid neoplasms (t-MNs) are severe long-term consequences of cytotoxic treatments for a primary, often, malignant disorder. So far, the majority of patients eligible for transplantation have undergone myeloablative allo haematopoietic SCT (HSCT) as a potentially curative treatment, but it has been associated with high transplantation-related mortality (TRM) rates. In this retrospective study, we analysed the outcome of patients with t-MNs undergoing HSCT with reduced-intensity conditioning (RIC). Of 55 patients, seen at a single centre over a 10-year period, 17 underwent RIC HSCT with related or unrelated donors. The estimated overall survival was 53% at 1 year and 47% at 3 years, and disease-free survival was 47% at 1 year. At 1 year, the cumulative incidence of relapse and TRM were 24% and 30%, respectively. Of five patients with active primary neoplasms who underwent transplantation, two are alive beyond 1 year and show CR of both t-MNs and the primary malignancy. These data indicate that RIC HSCT is an encouraging approach for patients with t-MNs. The issue of primary malignancies not being in remission at the time of transplantation should be explored in further studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Disease-Free Survival -
- Female -
- Hematologic Neoplasms - mortality
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Male -
- Middle Aged -
- Retrospective Studies -
- Survival Rate -
- Time Factors -
- Transplantation Conditioning -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- therapy-related myeloid neoplasms
- reduced-intensity allografting
- graft-vs-primary malignancy