Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Verhoest, G; Shariat, SF; Chromecki, TF; Raman, JD; Margulis, V; Novara, G; Seitz, C; Remzi, M; Rouprêt, M; Scherr, DS; Bensalah, K.
Predictive factors of recurrence and survival of upper tract urothelial carcinomas.
World J Urol. 2011; 29(4):495-501
Doi: 10.1007/s00345-011-0710-3
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- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
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- Abstract:
- UTUCC is a rare tumor, and most reports on prognostic factors come from small single-center series. The objective of this article was to provide an updated overview of current clinical, pathological and biological prognostic factors of UTUC. PubMed was searched for records from 2002 to 2010 using the terms "prognostic factors", "recurrence", "survival", and "upper tract urothelial carcinoma". Among identified citations, papers were selected based on their clinical relevance. Classical clinical factors that influence UTUC prognosis include age, presence of symptoms, hydronephrosis, and interval from diagnosis. Many biomarkers have shown promises to better appraise the natural course of UTUC although none is currently used in clinical practice. Stage, grade, lymph node metastases, lymphovascular invasion, tumor necrosis, and tumor architecture are strong pathological parameters. RNU is the standard treatment of localized UTUC. Both laparoscopic and open approaches seem to offer similar cancer control. Lymph node dissection increases staging accuracy and might confer a survival benefit. RNU is the standard treatment for most patients with UTUC. Recent multicenter studies confirmed the prognostic value of classical prognostic parameters. Better survival prediction might be obtained with prognostic systems including clinical data and new biomarkers.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma - epidemiology
- Female -
- Humans -
- Male -
- Neoplasm Recurrence, Local - epidemiology
- Predictive Value of Tests -
- Prognosis -
- Survival Rate -
- Urologic Neoplasms - epidemiology
- Urologic Surgical Procedures -
- Urothelium - pathology
- Find related publications in this database (Keywords)
- Transitional carcinoma
- Upper tract
- Nephroureterectomy
- Predictive factors
- Recurrence
- Urothelial carcinoma