Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Orendi, K; Klein, K; Krampl-Bettelheim, E; Nuk, M; Holzapfel-Bauer, M; Magnet, E; Griesbacher, A; Lang, U; Pertl, B.
SRY-specific cell free fetal DNA in maternal plasma in twin pregnancies throughout gestation.
Placenta. 2011; 32(8):611-615
Doi: 10.1016/j.placenta.2011.03.009
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Aubell Kristina
- Pertl Barbara
- Co-Autor*innen der Med Uni Graz
- Griesbacher Antonia
- Holzapfel-Bauer Margit
- Lang Uwe
- Magnet Eva Maria Sieglinde
- Nuk Monika
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- Abstract:
- Levels of SRY-specific cell free fetal DNA (SRY-cffDNA) in maternal plasma were investigated in twin pregnancies with two male fetuses versus one male and one female fetus and singleton male pregnancies during second and third trimester. The aim was to evaluate at which gestational age the amount of SRY-cffDNA reflects the number of fetuses and placentas respectively. 251 venous blood samples were analyzed from a total of 178 women with male or mixed-gender twin pregnancies and male singleton pregnancies in the second and the third trimester. The concentration of SRY-cffDNA was determined by quantitative real time PCR using the Y-chromosome specific SRY assay. For statistical analysis these three groups were divided into four subgroups according to their gestational age. During second trimester levels of SRY-cffDNA showed no differences between twin and singleton pregnancies. After 28 weeks SRY-cffDNA of male twin pregnancies was significantly increased compared to singleton male pregnancies and mixed-gender twin pregnancies with no differences between the latter two. The level of SRY-cffDNA in maternal serum of twin pregnancies reflects the number of fetuses only during the third trimester. Hence its use as a diagnostic tool for complications related to altered SRY-cffDNA levels in twin pregnancies should be evaluated at different weeks of gestation, especially during the second trimester. Copyright © 2011 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- DNA - blood
- Female -
- Fetus -
- Gestational Age -
- Humans -
- Male -
- Pregnancy -
- Pregnancy Trimester, Second -
- Pregnancy Trimester, Third -
- Pregnancy, Twin - genetics
- Sex-Determining Region Y Protein - genetics
- Find related publications in this database (Keywords)
- cffDNA
- Twins
- SRY
- Maternal plasma