Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hinghofer-Szalkay, H; Lackner, HK; Rössler, A; Narath, B; Jantscher, A; Goswami, N.
Hormonal and plasma volume changes after presyncope.
Eur J Clin Invest. 2011; 41(11): 1180-1185.
Doi: 10.1111/j.1365-2362.2011.02523.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Co-Autor*innen der Med Uni Graz
- Goswami Nandu
- Jantscher Andreas
- Lackner Helmut Karl
- Narath Bettina
- Rössler Andreas
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- Abstract:
- BACKGROUND: Aim of this study was to test the hypothesis that after presyncope, some blood hormone pools increase while others decrease. MATERIALS AND METHODS: In twelve healthy male adults, we determined plasma volume changes with plasma mass densitometry and hormone levels. The following were compared: supine rest, presyncope and 20-min post-presyncopal supine rest. We determined plasma renin activity (PRA), aldosterone, adrenocorticotropic hormone (ACTH), adrenomedullin and vasopressin (AVP) from venous blood samples. RESULTS: Using passive 4-min 70° head-up tilt followed by 4-min sequences of additional lower body negative pressure of increasing intensity (15 mmHg steps), presyncope occurred after 11·6 ± 2·8 min, at which time plasma volume was reduced by 15·5 ± 7·4%, aldosterone increased by 37%, ACTH by 75%, PRA by 187% and AVP about 16-fold in average (all P < 0·01); no significant changes in adrenomedullin were seen. Twenty-min post-presyncope, ACTH increased above presyncopal levels (+36%, P < 0·05), aldosterone by 35% (P = 0·07). PRA (-47%, P < 0·01) and AVP (-84%, P < 0·05) decreased below presyncopal but were still above supine control (P < 0·01); similarly, plasma density fell by 2·17 ± 0·97 g L(-1) below presyncopal (P < 0·01), but above supine control (P < 0·05), indicating rapid recovery (83% of initial plasma volume). CONCLUSIONS: We conclude that during the 20-min supine post-syncopal period, plasma volume, PRA and AVP return closer to baseline but aldosterone and ACTH continue increasing. The magnitude of observed concentration changes cannot be explained by haemoconcentration/haemodilution, rather it appears that the observed changes are indicative of hormone-specific endocrine activation patterns in the recovery phase.
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation. - Find related publications in this database (using NLM MeSH Indexing)
- Adrenocorticotropic Hormone - blood
- Adrenomedullin - blood
- Adult -
- Aldosterone - blood
- Head-Down Tilt - physiology
- Humans -
- Male -
- Plasma Volume - physiology
- Renin - blood
- Syncope - blood
- Tilt-Table Test - methods
- Vasopressins - blood
- Young Adult -
- Find related publications in this database (Keywords)
- ACTH
- Aldosterone
- Hormones
- LBNP
- Passive head-up tilt
- PRA