Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eller, K; Wolf, D; Huber, JM; Metz, M; Mayer, G; McKenzie, AN; Maurer, M; Rosenkranz, AR; Wolf, AM.
IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.
J Immunol. 2011; 186(1):83-91
Doi: 10.4049/jimmunol.1001183
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Rosenkranz Alexander
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- Abstract:
- Both mast cells (MCs) and regulatory T cells (Tregs) have gained attention as immunosuppressive cell populations. To investigate a possible interaction, we used the Th1- and Th17-dependent model of nephrotoxic serum nephritis (NTS), in which both MCs and Tregs have been shown to play a protective role. Transfer of wild-type (wt) Tregs into wt recipients almost completely prevents development of NTS and leads to a profound increase of MCs in the renal draining lymph nodes (LNs). By contrast, transfer of wt Tregs into animals deficient in MCs, which are characterized by an exaggerated susceptibility to NTS, no longer exhibited protective effects. Blocking the pleiotropic cytokine IL-9, known to be involved in MC recruitment and proliferation, by means of a mAb in mice receiving Tregs abrogated protection from NTS. Moreover, transfer of IL-9-deficient Tregs also failed to protect from NTS. In the absence of Treg-derived IL-9, MCs fail to accumulate in the LNs, despite the fact that IL-9 deficiency does not alter the general suppressive activity of Tregs. In summary, to our knowledge, we provide the first direct in vivo evidence that the nephroprotective, anti-inflammatory effects of Tregs critically depend on IL-9-mediated attraction of MCs into kidney-draining LNs.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adoptive Transfer -
- Animals -
- Cell Communication - immunology
- Cell Movement - immunology
- Immunosuppression - methods
- Inflammation Mediators - metabolism Inflammation Mediators - physiology
- Interleukin-9 - biosynthesis Interleukin-9 - deficiency Interleukin-9 - physiology
- Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology
- Mast Cells - immunology Mast Cells - pathology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Nephritis - immunology Nephritis - pathology Nephritis - prevention and control
- T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - transplantation