Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Meyer, T; Stanske, B; Kochen, MM; Cordes, A; Yüksel, I; Wachter, R; Lüers, C; Scherer, M; Binder, L; Pieske, B; Herrmann-Lingen, C.
Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors.
Psychosomatics. 2010; 51(3):248-256
Doi: 10.1176/appi.psy.51.3.248
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Background: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines. Objective: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors. Method: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N = 178) who were assigned to the highest and lowest quartiles of the MQ, respectively. Results: Elevated serum concentrations of interleukin-6 and tumor necrosis factor alpha, but not other cytokines, were associated with high MQ scores indicative of vital exhaustion. Conclusion: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and antiinflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion. (Psychosomatics 2010; 51: 248-256)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged -
- Cardiovascular Diseases - genetics
- Cohort Studies -
- Coronary Disease - genetics
- Fatigue - genetics
- Female -
- Heart Failure - genetics
- Humans -
- Interleukin-10 - blood
- Interleukin-6 - blood
- Irritable Mood - physiology
- Male -
- Middle Aged -
- Morale -
- Personality Inventory - statistics & numerical data
- Primary Health Care -
- Psychometrics -
- Risk Factors -
- Tumor Necrosis Factor-alpha - blood