Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lederer, AJ; Bornemann-Cimenti, H; Wejbora, M; Kern-Pirsch, C; Michaeli, K; Sandner-Kiesling, A.
Pregabalin and postoperative hyperalgesia : A review.
Schmerz. 2011; 25(1): 12-18.
Doi: 10.1007/s00482-010-1008-x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Sandner-Kiesling Andreas
- Co-Autor*innen der Med Uni Graz
- Bornemann-Cimenti Helmar
- Kern-Pirsch Claudia
- Michaeli Kristina Daniela
- Wejbora Mischa
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- Abstract:
- Numerous studies support the theory that pregabalin causes an antihyperalgesic effect, which could be potentially beneficial in a perioperative setting. By binding to calcium channels pregabalin reduces the release of excitatory neurotransmitters and therefore inhibits central sensitization. Animal studies clearly demonstrated the antihyperalgesic potency of pregabalin but human experiments are, however, inconclusive. Clinical studies with quantitative sensory testing have not yet been published. Although strongly supported by theoretical considerations the routine preoperative application of pregabalin for the prevention of hyperalgesia cannot be recommended due to the lack of clinical studies. Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters.
- Find related publications in this database (using NLM MeSH Indexing)
- Analgesics - adverse effects
- Animals -
- Calcium Channels - drug effects
- Disease Models, Animal -
- Humans -
- Hyperalgesia - drug therapy
- Pain, Postoperative - drug therapy
- Premedication -
- gamma-Aminobutyric Acid - adverse effects
- Find related publications in this database (Keywords)
- Hyperalgesia
- Allodynia
- Pain, postoperative
- Pregabalin
- Premedication