Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Warncke, K; Fröhlich-Reiterer, EE; Thon, A; Hofer, SE; Wiemann, D; Holl, RW; on behalf of the DPV-Initiative of the German working group for pediatric diabetology and the German BMBF Competency Network for Diabetes Mellitus.
Polyendocrinopathy in Children, Adolescents, and Young Adults With Type 1 Diabetes: A multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database.
Diabetes Care. 2010; 33(9):2010-2012
Doi: 10.2337/dc10-0404
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- Co-Autor*innen der Med Uni Graz
- Fröhlich-Reiterer Elke
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- Abstract:
- OBJECTIVE - To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a large cohort of young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Data from 28,671 patients <30 years with type 1 diabetes from 242 specialized centers in Germany and Austria were analyzed. RESULTS - At least one beta-cell antibody was present in 81.6% of patients. beta-cell Ab-negative patients were significantly younger at diabetes onset (P < 0.0001). A total of 19.6% had positive thyroid antibodies with female predominance (62%, P < 0.0001). Antibodies to tissue transglutaminase were present in 10.7%, with a significantly longer duration of diabetes (P < 0.0001). Parietal cell antibodies were found in 283 patients, associated with older age (P < 0.001), and adrenal antibodies were present in 94 patients. In 575 patients, at least three different autoimmune phenomena were present. CONCLUSIONS - Thyroid autoimmunity and antibodies suggestive for celiac disease are the most prevalent additional immune phenomena in type 1 diabetes. Parietal/adrenal antibodies are rare.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Adult -
- Autoimmunity - immunology
- Celiac Disease - immunology
- Child -
- Child, Preschool -
- Diabetes Mellitus, Type 1 - complications
- Female -
- Female -
- Humans -
- Infant -
- Infant, Newborn -
- Insulin-Secreting Cells - immunology
- Male -
- Polyendocrinopathies, Autoimmune - etiology
- Thyroid Gland - immunology
- Young Adult -