Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schienle, A; Köchel, A; Ebner, F; Reishofer, G; Schäfer, A.
Neural correlates of intolerance of uncertainty.
Neurosci Lett. 2010; 479(3): 272-276.
Doi: 10.1016/j.neulet.2010.05.078
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Ebner Franz
- Reishofer Gernot
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- Abstract:
- Many future events are unpredictable, which is considered unacceptable by individuals with an intolerance of uncertainty (IU). We investigated the influence of two related personality traits, IU and habitual worrying on neural correlates of affective uncertainty with functional magnetic resonance imaging. Thirty females viewed a warning cue that always preceded an aversive picture, a safety cue that always preceded a neutral picture and an uncertainty cue that signaled that an aversive or a neutral picture might be shown (probability: 50%:50%). The processing of uncertainty was associated with activation of the posterior frontomedian cortex (PFMC), the dorsolateral prefrontal cortex, and the anterior cingulate cortex. IU and habitual worrying were positively correlated with amygdala activity during experienced uncertainty. Moreover, IU correlated negatively with PFMC activity. This response pattern might reflect that uncertainty is threatening to individuals high in IU and that they lack adequate cognitive mechanism to cope with the uncertainty. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Affect -
- Brain - anatomy and histology
- Brain Mapping -
- Emotions -
- Female -
- Humans -
- Magnetic Resonance Imaging -
- Photic Stimulation -
- Uncertainty -
- Young Adult -
- Find related publications in this database (Keywords)
- Uncertainty
- fMRI
- Posterior frontomedian cortex