Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pagani, E; Hirsch, JG; Pouwels, PJ; Horsfield, MA; Perego, E; Gass, A; Roosendaal, SD; Barkhof, F; Agosta, F; Rovaris, M; Caputo, D; Giorgio, A; Palace, J; Marino, S; De Stefano, N; Ropele, S; Fazekas, F; Filippi, M.
Intercenter differences in diffusion tensor MRI acquisition.
J Magn Reson Imaging. 2010; 31(6): 1458-1468.
Doi: 10.1002/jmri.22186
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- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Ropele Stefan
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- Abstract:
- Purpose: To assess the effect on diffusion tensor (DT) magnetic resonance imaging (MRI) of acquiring data with different scanners. Materials and Methods: Forty-four healthy controls and 36 multiple sclerosis patients with low disability were studied using eight MR scanners with acquisition protocols that were as close to a standard protocol as possible. Between 7 and 13 subjects were studied in each center. Region-of-interest (ROI) and histogram-based analyses of fractional anisotropy (FA), axial (D-ax), radial (D-rad), and mean diffusivity (MD) were performed. The influence of variables such as the acquisition center and the control/patient group was determined with an analysis of variance (ANOVA) test. Results: The patient/control group explained approximate to 25% of data variability of FA and Drad from midsagittal corpus callosum (CC) ROIs. Global FA, MD, and Drad in the white matter differentiated patients from controls, but with lower discriminatory power than for the CC. In the gray matter, MD discriminated patients from controls (30% of variability explained by group vs. 17% by center). Conclusion: Significant variability of DT-MRI data can be attributed to the acquisition center, even when a standardized protocol is used. The use of appropriate segmentation methods and statistical models allows DT-derived metrics to differentiate patients from healthy controls.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Case-Control Studies -
- Corpus Callosum - pathology
- Diffusion -
- Diffusion Magnetic Resonance Imaging - methods
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Male -
- Middle Aged -
- Multiple Sclerosis - diagnosis
- Prospective Studies -
- Reproducibility of Results -
- Water - chemistry
- Find related publications in this database (Keywords)
- DT-MRI
- multicenter acquisition
- data variability