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Search Items: PROTO-ONCOGENE PROTEINS C-AKT - METABOLISM , . hits: 39

2023

Krassnig, S; Leber, SL; Orthmann, A; Golob-Schwarzl, N; Huber, HJ; Wohlrab, C; Skofler, C; Pennauer, M; Raicht, A; Birkl-Toeglhofer, AM; Naumann, M; Mahdy-Ali, K; von, Campe, G; Leoni, M; Alcaniz, J; Hoffmann, J; Wälchli, T; Weis, S; Benesch, M; Haybaeck, J Decreased eukaryotic initiation factors expression upon temozolomide treatment-potential novel implications for eIFs in glioma therapy.
J Neurooncol. 2023; 165(1):91-100 Doi: 10.1007/s11060-023-04451-y [OPEN ACCESS]
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2020

Golob-Schwarzl, N; Puchas, P; Gogg-Kamerer, M; Weichert, W; Göppert, B; Haybaeck, J New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma.
Anticancer Res. 2020; 40(6):3109-3118 Doi: 10.21873/anticanres.14292 [OPEN ACCESS]
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2018

Wan, S; Meyer, AS; Weiler, SME; Rupp, C; Tóth, M; Sticht, C; Singer, S; Thomann, S; Roessler, S; Schorpp-Kistner, M; Schmitt, J; Gretz, N; Angel, P; Tschaharganeh, DF; Marquardt, J; Schirmacher, P; Pinna, F; Breuhahn, K Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness.
Hepatology. 2018; 67(5): 1842-1856. Doi: 10.1002/hep.29669
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2017

Golob-Schwarzl, N; Krassnig, S; Toeglhofer, AM; Park, YN; Gogg-Kamerer, M; Vierlinger, K; Schröder, F; Rhee, H; Schicho, R; Fickert, P; Haybaeck, J New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Eur J Cancer. 2017; 83(60):56-70 Doi: 10.1016/j.ejca.2017.06.003
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Riedl, A; Schlederer, M; Pudelko, K; Stadler, M; Walter, S; Unterleuthner, D; Unger, C; Kramer, N; Hengstschläger, M; Kenner, L; Pfeiffer, D; Krupitza, G; Dolznig, H Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
J Cell Sci. 2017; 130(1):203-218 Doi: 10.1242/jcs.188102 [OPEN ACCESS]
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Wagner, G; Lindroos-Christensen, J; Einwallner, E; Husa, J; Zapf, TC; Lipp, K; Rauscher, S; Gröger, M; Spittler, A; Loewe, R; Gruber, F; Duvigneau, JC; Mohr, T; Sutterlüty-Fall, H; Klinglmüller, F; Prager, G; Huppertz, B; Yun, J; Wagner, O; Esterbauer, H; Bilban, M HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2.
Sci Rep. 2017; 7(4):40881-40881 Doi: 10.1038/srep40881 [OPEN ACCESS]
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Wu, BJ; Li, Y; Ong, KL; Sun, Y; Shrestha, S; Hou, L; Johns, D; Barter, PJ; Rye, KA Reduction of In-Stent Restenosis by Cholesteryl Ester Transfer Protein Inhibition.
ARTERIOSCL THROM VAS. 2017; 37(12): 2333-2341. Doi: 10.1161/ATVBAHA.117.310051 [OPEN ACCESS]
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2016

Koyani, CN; Kitz, K; Rossmann, C; Bernhart, E; Huber, E; Trummer, C; Windischhofer, W; Sattler, W; Malle, E Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
Biochem Pharmacol. 2016; 104:29-41 Doi: 10.1016/j.bcp.2016.01.011 [OPEN ACCESS]
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Verbrugge, SE; Al, M; Assaraf, YG; Kammerer, S; Chandrupatla, DM; Honeywell, R; Musters, RP; Giovannetti, E; O'Toole, T; Scheffer, GL; Krige, D; de Gruijl, TD; Niessen, HW; Lems, WF; Kramer, PA; Scheper, RJ; Cloos, J; Ossenkoppele, GJ; Peters, GJ; Jansen, G Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Oncotarget. 2016; 7(5):5240-5257 Doi: 10.18632/oncotarget.6169 [OPEN ACCESS]
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2015

Krassnig, S; Schweinzer, C; Taub, N; Havas, D; Auer, E; Flunkert, S; Schreibmayer, W; Hutter-Paier, B; Windisch, M Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.
Neurodegener Dis. 2015; 15(4):243-257 Doi: 10.1159/000430952
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Obenauf, AC; Zou, Y; Ji, AL; Vanharanta, S; Shu, W; Shi, H; Kong, X; Bosenberg, MC; Wiesner, T; Rosen, N; Lo, RS; Massagué, J Therapy-induced tumour secretomes promote resistance and tumour progression.
Nature. 2015; 520(7547): 368-372. Doi: 10.1038/nature14336 [OPEN ACCESS]
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Scazzocchio, B; Varì, R; Filesi, C; Del Gaudio, I; D'Archivio, M; Santangelo, C; Iacovelli, A; Galvano, F; Pluchinotta, FR; Giovannini, C; Masella, R Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity.
Mol Nutr Food Res. 2015; 59(8):1472-1481 Doi: 10.1002/mnfr.201400816
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Schwarzl, M; Hamdani, N; Seiler, S; Alogna, A; Manninger, M; Reilly, S; Zirngast, B; Kirsch, A; Steendijk, P; Verderber, J; Zweiker, D; Eller, P; Höfler, G; Schauer, S; Eller, K; Maechler, H; Pieske, BM; Linke, WA; Casadei, B; Post, H A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
Am J Physiol Heart Circ Physiol. 2015; 309(9):H1407-18 Doi: 10.1152/ajpheart.00542.2015 [OPEN ACCESS]
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Sturm, EM; Parzmair, GP; Radnai, B; Frei, RB; Sturm, GJ; Hammer, A; Schuligoi, R; Lippe, IT; Heinemann, A Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Eur J Immunol. 2015; 45(5):1548-1559 Doi: 10.1002/eji.201445196 [OPEN ACCESS]
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Wende, AR; O'Neill, BT; Bugger, H; Riehle, C; Tuinei, J; Buchanan, J; Tsushima, K; Wang, L; Caro, P; Guo, A; Sloan, C; Kim, BJ; Wang, X; Pereira, RO; McCrory, MA; Nye, BG; Benavides, GA; Darley-Usmar, VM; Shioi, T; Weimer, BC; Abel, ED Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.
Mol Cell Biol. 2015; 35(5): 831-846. Doi: 10.1128/MCB.01109-14 [OPEN ACCESS]
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Zakharova, IO; Sokolova, TV; Akhmetshina, AO; Avrova, NF Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2.
Bull Exp Biol Med. 2015; 159(5): 610-613. Doi: 10.1007/s10517-015-3026-2
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Zanini, S; Giovinazzo, F; Alaimo, D; Lawrence, B; Pfragner, R; Bassi, C; Modlin, I; Kidd, M GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.
Cell Signal. 2015; 27(5):899-907 Doi: 10.1016/j.cellsig.2015.02.001
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Zhao, Q; Assimopoulou, AN; Klauck, SM; Damianakos, H; Chinou, I; Kretschmer, N; Rios, JL; Papageorgiou, VP; Bauer, R; Efferth, T Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
Oncotarget. 2015; 6(36):38934-38951 Doi: 10.18632/oncotarget.5380 [OPEN ACCESS]
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Zhao, Q; Kretschmer, N; Bauer, R; Efferth, T Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.
Int J Cancer. 2015; 137(6):1446-1456 Doi: 10.1002/ijc.29483 [OPEN ACCESS]
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2014

Dengler, MA; Weilbacher, A; Gutekunst, M; Staiger, AM; Vöhringer, MC; Horn, H; Ott, G; Aulitzky, WE; van der Kuip, H Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma.
Cell Death Dis. 2014; 5(8):e1013-e1013 Doi: 10.1038/cddis.2013.552 [OPEN ACCESS]
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Kiss, T; Kovacs, K; Komocsi, A; Tornyos, A; Zalan, P; Sumegi, B; Gallyas, F; Kovacs, K Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases and Akt.
PLoS One. 2014; 9(8): e104890 Doi: 10.1371/journal.pone.0104890 [OPEN ACCESS]
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Quan, P; Moinfar, F; Kufferath, I; Absenger, M; Kueznik, T; Denk, H; Zatloukal, K; Haybaeck, J Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling.
Anticancer Res. 2014; 34(6):2883-2897
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2013

Fock, V; Mairhofer, M; Otti, GR; Hiden, U; Spittler, A; Zeisler, H; Fiala, C; Knöfler, M; Pollheimer, J Macrophage-derived IL-33 is a critical factor for placental growth.
J Immunol. 2013; 191(7):3734-3743 Doi: 10.4049/jimmunol.1300490 [OPEN ACCESS]
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Lassance, L; Miedl, H; Absenger, M; Diaz-Perez, F; Lang, U; Desoye, G; Hiden, U Hyperinsulinemia stimulates angiogenesis of human fetoplacental endothelial cells: a possible role of insulin in placental hypervascularization in diabetes mellitus.
J Clin Endocrinol Metab. 2013; 98(9):E1438-E1447 Doi: 10.1210/jc.2013-1210 [OPEN ACCESS]
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Svejda, B; Kidd, M; Timberlake, A; Harry, K; Kazberouk, A; Schimmack, S; Lawrence, B; Pfragner, R; Modlin, IM Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors.
Cancer Sci. 2013; 104(7):844-855 Doi: 10.1111/cas.12174 [OPEN ACCESS]
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2012

Hafner, C; Houben, R; Baeurle, A; Ritter, C; Schrama, D; Landthaler, M; Becker, JC Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS One. 2012; 7(2):e31255-e31255 Doi: 10.1371/journal.pone.0031255 [OPEN ACCESS]
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Radnai, B; Antus, C; Racz, B; Engelmann, P; Priber, JK; Tucsek, Z; Veres, B; Turi, Z; Lorand, T; Sumegi, B; Gallyas, F Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Mol Cancer. 2012; 11(5): 34-34. Doi: 10.1186/1476-4598-11-34 [OPEN ACCESS]
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Veith, C; Marsh, LM; Wygrecka, M; Rutschmann, K; Seeger, W; Weissmann, N; Kwapiszewska, G Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.
Am J Pathol. 2012; 181(5):1621-1633 Doi: 10.1016/j.ajpath.2012.07.026 [OPEN ACCESS]
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Wygrecka, M; Zakrzewicz, D; Taborski, B; Didiasova, M; Kwapiszewska, G; Preissner, KT; Markart, P TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner.
Am J Respir Cell Mol Biol. 2012; 47(5):614-627 Doi: 10.1165/rcmb.2012-0097OC
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2011

März-Weiss, P; Kunz, D; Bimmler, D; Berkemeier, C; Özbek, S; Dimitriades-Schmutz, B; Haybaeck, J; Otten, U; Graf, R Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain.
Cell Mol Neurobiol. 2011; 31(8):1141-1149 Doi: 10.1007/s10571-011-9715-0
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Steinbrunn, T; Stuhmer, T; Gattenlohner, S; Rosenwald, A; Mottok, A; Unzicker, C; Einsele, H; Chatterjee, M; Bargou, RC Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival.
Blood. 2011; 117(6):1998-2004 Doi: 10.1182/blood-2010-05-284422 [OPEN ACCESS]
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Svejda, B; Kidd, M; Kazberouk, A; Lawrence, B; Pfragner, R; Modlin, IM Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT.
CANCER-AM CANCER SOC. 2011; 117(18): 4141-4154. Doi: 10.1002/cncr.26011 [OPEN ACCESS]
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Watzka, SB; Setinek, U; Stubenberger, EB; Totsch, M; Dekan, G; Marcher, M; Fleck, T; Muller, MR Integrin-linked kinase, phosphorylated AKT and the prognosis of malignant pleural mesothelioma
EUR J CARDIO-THORAC SURG. 2011; 39(2): 180-184. Doi: 10.1016/j.ejcts.2010.05.007 [OPEN ACCESS]
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2010

Doi, T; Ruttenstock, E; Dingemann, J; Puri, P Spatiotemporal alteration in phosphatidylinositide 3-kinase-serine/threonine protein kinase B signaling in the nitrofen-induced hypoplastic lung.
J Pediatr Surg. 2010; 45(2):366-371 Doi: 10.1016/j.jpedsurg.2009.10.075
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2008

Bernhard, EJ; Brunner, TB Progress towards the use of HIV protease inhibitors in cancer therapy.
Cancer Biol Ther. 2008; 7(5):636-7 Doi: 10.4161/cbt.7.5.6087
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Mantoni, TS; Schendel, RR; Rödel, F; Niedobitek, G; Al-Assar, O; Masamune, A; Brunner, TB Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma.
Cancer Biol Ther. 2008; 7(11):1806-15 Doi: 10.4161/cbt.7.11.6846
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Zollinger, A; Stuhmer, T; Chatterjee, M; Gattenlohner, S; Haralambieva, E; Muller-Hermelink, HK; Andrulis, M; Greiner, A; Wesemeier, C; Rath, JC; Einsele, H; Bargou, RC Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma.
Blood. 2008; 112(8):3403-3411 Doi: 10.1182/blood-2007-11-119362 [OPEN ACCESS]
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2006

Isoda, K; Young, JL; Zirlik, A; MacFarlane, LA; Tsuboi, N; Gerdes, N; Schönbeck, U; Libby, P Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.
ARTERIOSCL THROM VAS. 2006; 26(3): 611-617. Doi: 10.1161/01.ATV.0000201938.78044.75 [OPEN ACCESS]
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2004

Hobom, M; Storch, MK; Weissert, R; Maier, K; Radhakrishnan, A; Kramer, B; Bähr, M; Diem, R Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis.
Brain Pathol. 2004; 14(2):148-157 Doi: 10.1111/j.1750-3639.2004.tb00047.x
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