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Search Items: APOPTOSIS - DRUG EFFECTS , . hits: 149

2021

Kretschmer, N; Hufner, A; Durchschein, C; Popodi, K; Rinner, B; Lohberger, B; Bauer, R Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives.
Int J Mol Sci. 2021; 22(5): Doi: 10.3390/ijms22052774 [OPEN ACCESS]
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Lohberger, B; Scheipl, S; Heitzer, E; Quehenberger, F; de, Jong, D; Szuhai, K; Liegl-Atzwanger, B; Rinner, B Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma.
Sci Rep. 2021; 11(1): 12466 Doi: 10.1038/s41598-021-92018-0 [OPEN ACCESS]
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Mikulčić, M; Tabrizi-Wizsy, NG; Bernhart, EM; Asslaber, M; Trummer, C; Windischhofer, W; Sattler, W; Malle, E; Hrzenjak, A 15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111760 [OPEN ACCESS]
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Thorne, LS; Rochford, G; Williams, TD; Southam, AD; Rodriguez-Blanco, G; Dunn, WB; Hodges, NJ Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Sci Rep. 2021; 11(1): 985 Doi: 10.1038/s41598-020-79830-w [OPEN ACCESS]
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2020

Jayavelu, AK; Schnöder, TM; Perner, F; Herzog, C; Meiler, A; Krishnamoorthy, G; Huber, N; Mohr, J; Edelmann-Stephan, B; Austin, R; Brandt, S; Palandri, F; Schröder, N; Isermann, B; Edlich, F; Sinha, AU; Ungelenk, M; Hübner, CA; Zeiser, R; Rahmig, S; Waskow, C; Coldham, I; Ernst, T; Hochhaus, A; Jilg, S; Jost, PJ; Mullally, A; Bullinger, L; Mertens, PR; Lane, SW; Mann, M; Heidel, FH Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Nature. 2020; 588(7836):157-163 Doi: 10.1038/s41586-020-2968-3
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Martínez, R; Geronimo, BD; Pastor, M; Zapico, JM; Coderch, C; Panchuk, R; Skorokhyd, N; Maslyk, M; Ramos, A; de, Pascual-Teresa, B Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors.
Molecules. 2020; 25(7): Doi: 10.3390/molecules25071497 [OPEN ACCESS]
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Santiago-Fernández, C; Martin-Reyes, F; Tome, M; Ocaña-Wilhelmi, L; Rivas-Becerra, J; Tatzber, F; Pursch, E; Tinahones, FJ; García-Fuentes, E; Garrido-Sánchez, L Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile.
BIOMOLECULES. 2020; 10(4): Doi: 10.3390/biom10040534 [OPEN ACCESS]
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Scherr, AL; Mock, A; Gdynia, G; Schmitt, N; Heilig, CE; Korell, F; Rhadakrishnan, P; Hoffmeister, P; Metzeler, KH; Schulze-Osthoff, K; Illert, AL; Boerries, M; Trojan, J; Waidmann, O; Falkenhorst, J; Siveke, J; Jost, PJ; Bitzer, M; Malek, NP; Vecchione, L; Jelas, I; Brors, B; Glimm, H; Stenzinger, A; Grekova, SP; Gehrig, T; Schulze-Bergkamen, H; Jäger, D; Schirmacher, P; Heikenwalder, M; Goeppert, B; Schneider, M; Fröhling, S; Köhler, BC Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer.
Cell Death Dis. 2020; 11(10):875 Doi: 10.1038/s41419-020-03092-7 [OPEN ACCESS]
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2019

Pansy, K; Feichtinger, J; Ehall, B; Uhl, B; Sedej, M; Roula, D; Pursche, B; Wolf, A; Zoidl, M; Steinbauer, E; Gruber, V; Greinix, HT; Prochazka, KT; Thallinger, GG; Heinemann, A; Beham-Schmid, C; Neumeister, P; Wrodnigg, TM; Fechter, K; Deutsch, AJ The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro.
Int J Mol Sci. 2019; 20(19): Doi: 10.3390/ijms20194740 [OPEN ACCESS]
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Theiler, A; Bärnthaler, T; Platzer, W; Richtig, G; Peinhaupt, M; Rittchen, S; Kargl, J; Ulven, T; Marsh, LM; Marsche, G; Schuligoi, R; Sturm, EM; Heinemann, A Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival.
J Allergy Clin Immunol. 2019; 144(3):764-776 Doi: 10.1016/j.jaci.2019.05.002 [OPEN ACCESS]
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2018

Jahanafrooz, Z; Stallinger, A; Anders, I; Kleinegger, F; Lohberger, B; Durchschein, C; Bauer, R; Deutsch, A; Rinner, B; Kretschmer, N Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells.
Phytomedicine. 2018; 49(11):32-40 Doi: 10.1016/j.phymed.2018.06.005
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2017

Bonyadi Rad, E; Mostofi, S; Katschnig, M; Schmutz, P; Pawelkiewicz, M; Willumeit-Römer, R; Schäfer, U; Weinberg, A Differential apoptotic response of MC3T3-E1 pre-osteoblasts to biodegradable magnesium alloys in an in vitro direct culture model.
J Mater Sci Mater Med. 2017; 28(10):155-155 Doi: 10.1007/s10856-017-5969-5 [OPEN ACCESS]
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Enzenhofer, E; Kadletz, L; Stanisz, I; Kotowski, U; Seemann, R; Schmid, R; Thurnher, D; Heiduschka, G Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines.
Head Neck. 2017; 39(5):900-907 Doi: 10.1002/hed.24699
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Madreiter-Sokolowski, CT; Sokolowski, AA; Graier, WF Dosis Facit Sanitatem-Concentration-Dependent Effects of Resveratrol on Mitochondria.
Nutrients. 2017; 9(10): Doi: 10.3390/nu9101117 [OPEN ACCESS]
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Račkauskas, R; Zhou, D; Ūselis, S; Strupas, K; Herr, I; Schemmer, P Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti-apoptotic proteins.
Oncol Rep. 2017; 37(6):3660-3666 Doi: 10.3892/or.2017.5622 [OPEN ACCESS]
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Staiger, AM; Duppel, J; Dengler, MA; van der Kuip, H; Vöhringer, MC; Aulitzky, WE; Rosenwald, A; Ott, G; Horn, H An analysis of the role of follicular lymphoma-associated fibroblasts to promote tumor cell viability following drug-induced apoptosis.
Leuk Lymphoma. 2017; 58(8):1922-1930 Doi: 10.1080/10428194.2016.1263841
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2016

Arriga, R; Caratelli, S; Coppola, A; Spagnoli, GC; Venditti, A; Amadori, S; Lanzilli, G; Lauro, D; Palomba, P; Sconocchia, T; Del Principe, MI; Maurillo, L; Buccisano, F; Capuani, B; Ferrone, S; Sconocchia, G Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage.
Oncotarget. 2016; 7(2): 2070-2079. Doi: 10.18632/oncotarget.6529 [OPEN ACCESS]
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Arvidsson, Y; Johanson, V; Pfragner, R; Wängberg, B; Nilsson, O Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells.
Neuroendocrinology. 2016; 103(5):578-591 Doi: 10.1159/000441849
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Koyani, CN; Kitz, K; Rossmann, C; Bernhart, E; Huber, E; Trummer, C; Windischhofer, W; Sattler, W; Malle, E Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
Biochem Pharmacol. 2016; 104:29-41 Doi: 10.1016/j.bcp.2016.01.011 [OPEN ACCESS]
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Madreiter-Sokolowski, CT; Gottschalk, B; Parichatikanond, W; Eroglu, E; Klec, C; Waldeck-Weiermair, M; Malli, R; Graier, WF Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Cell Physiol Biochem. 2016; 39(4):1404-1420 Doi: 10.1159/000447844 [OPEN ACCESS]
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Scheipl, S; Barnard, M; Cottone, L; Jorgensen, M; Drewry, DH; Zuercher, WJ; Turlais, F; Ye, H; Leite, AP; Smith, JA; Leithner, A; Möller, P; Brüderlein, S; Guppy, N; Amary, F; Tirabosco, R; Strauss, SJ; Pillay, N; Flanagan, AM EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J Pathol. 2016; 239(3):320-334 Doi: 10.1002/path.4729 [OPEN ACCESS]
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Schneider, S; Thurnher, D; Kadletz, L; Seemann, R; Brunner, M; Kotowski, U; Schmid, R; Lill, C; Heiduschka, G Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells.
Oral Dis. 2016; 22(8):797-804 Doi: 10.1111/odi.12552
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Vogl, F; Humpolickova, J; Amaro, M; Koller, D; Kofeler, H; Zenzmaier, E; Hof, M; Hermetter, A Role of protein kinase C delta in apoptotic signaling of oxidized phospholipids in RAW 264.7 macrophages
BBA-MOL CELL BIOL L. 2016; 1861(4): 320-330. Doi: 10.1016/j.bbalip.2015.12.009
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Wicki, S; Gurzeler, U; Wei-Lynn Wong, W; Jost, PJ; Bachmann, D; Kaufmann, T Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.
Cell Death Dis. 2016; 7(10):e2422-e2422 Doi: 10.1038/cddis.2016.311 [OPEN ACCESS]
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2015

Aguiriano-Moser, V; Svejda, B; Li, ZX; Sturm, S; Stuppner, H; Ingolic, E; Höger, H; Siegl, V; Meier-Allard, N; Sadjak, A; Pfragner, R Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells.
Mol Med Rep. 2015; 12(4):5003-5011 Doi: 10.3892/mmr.2015.4053 [OPEN ACCESS]
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Dehghan Esmatabadi, MJ; Farhangi, B; Safari, Z; Kazerooni, H; Shirzad, H; Zolghadr, F; Sadeghizadeh, M Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.
Asian Pac J Cancer Prev. 2015; 16(6):2473-2481 Doi: 10.7314/APJCP.2015.16.6.2473 [OPEN ACCESS]
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Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Bertsch, A; Olschewski, A; Olschewski, H; Hrzenjak, A Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization.
Mol Cancer. 2015; 14(8):4-4 Doi: 10.1186/1476-4598-14-4 [OPEN ACCESS]
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Fisser, MC; Rommer, A; Steinleitner, K; Heller, G; Herbst, F; Wiese, M; Glimm, H; Sill, H; Wieser, R Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.
Mol Carcinog. 2015; 54(12):1815-1819 Doi: 10.1002/mc.22252 [OPEN ACCESS]
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Froehlich, EV; Rinner, B; Deutsch, AJ; Meditz, K; Knausz, H; Troppan, K; Scheipl, S; Wibmer, C; Leithner, A; Liegl, B; Lohberger, B Examination of survivin expression in 50 chordoma specimens--A histological and in vitro study.
J Orthop Res. 2015; 33(5):771-778 Doi: 10.1002/jor.22819 [OPEN ACCESS]
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Fuchs, R; Schwach, G; Stracke, A; Meier-Allard, N; Absenger, M; Ingolic, E; Haas, HS; Pfragner, R; Sadjak, A The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT.
Anticancer Res. 2015; 35(1):31-38 [OPEN ACCESS]
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Fuchs, R; Stracke, A; Ebner, N; Zeller, CW; Raninger, AM; Schittmayer, M; Kueznik, T; Absenger-Novak, M; Birner-Gruenberger, R The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P.
Toxicology. 2015; 338(6):17-29 Doi: 10.1016/j.tox.2015.09.008 [OPEN ACCESS]
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Haymerle, G; Thurnher, D; Kadletz, L; Stanisz, I; Brunner, M; Kotowski, U; Enzenhofer, E; Heiduschka, G Assessment of caroverine as a potential chemotherapeutical agent in HNSCC cell lines.
Eur Arch Otorhinolaryngol. 2015; 272(11):3451-3456 Doi: 10.1007/s00405-014-3364-0
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Lohberger, B; Kretschmer, N; Bernhart, E; Rinner, B; Stuendl, N; Kaltenegger, H; Kahl, S; Bauer, R; Leithner, A 25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J Ethnopharmacol. 2015; 164(36):265-272 Doi: 10.1016/j.jep.2015.02.023
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Lohberger, B; Leithner, A; Stuendl, N; Kaltenegger, H; Kullich, W; Steinecker-Frohnwieser, B Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.
BMC Cancer. 2015; 15(3):891-891 Doi: 10.1186/s12885-015-1915-4 [OPEN ACCESS]
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Mangmool, S; Hemplueksa, P; Parichatikanond, W; Chattipakorn, N Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes.
Mol Endocrinol. 2015; 29(4): 583-596. Doi: 10.1210/me.2014-1346 [OPEN ACCESS]
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Mayr, C; Neureiter, D; Pichler, M; Berr, F; Wagner, A; Kiesslich, T; Namberger, K Cytotoxic effects of chemokine receptor 4 inhibition by AMD3100 in biliary tract cancer cells: Potential drug synergism with gemcitabine.
Mol Med Rep. 2015; 12(2):2247-2252 Doi: 10.3892/mmr.2015.3589 [OPEN ACCESS]
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Mayr, C; Wagner, A; Neureiter, D; Pichler, M; Jakab, M; Illig, R; Berr, F; Kiesslich, T The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells.
BMC Complement Altern Med. 2015; 15(6):194-194 Doi: 10.1186/s12906-015-0721-5 [OPEN ACCESS]
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Riedl, S; Leber, R; Rinner, B; Schaider, H; Lohner, K; Zweytick, D Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine.
Biochim Biophys Acta. 2015; 1848(11 Pt A):2918-2931 Doi: 10.1016/j.bbamem.2015.07.018 [OPEN ACCESS]
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2014

Forster, T; Rausch, V; Zhang, Y; Isayev, O; Heilmann, K; Schoensiegel, F; Liu, L; Nessling, M; Richter, K; Labsch, S; Nwaeburu, CC; Mattern, J; Gladkich, J; Giese, N; Werner, J; Schemmer, P; Gross, W; Gebhard, MM; Gerhauser, C; Schaefer, M; Herr, I Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.
Oncotarget. 2014; 5(6):1621-1634 Doi: 10.18632/oncotarget.1764 [OPEN ACCESS]
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Heiduschka, G; Bigenzahn, J; Brunner, M; Thurnher, D Resveratrol synergistically enhances the effect of etoposide in HNSCC cell lines.
Acta Otolaryngol. 2014; 134(10): 1071-1078. Doi: 10.3109/00016489.2014.888592
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Heiduschka, G; Lill, C; Schneider, S; Seemann, R; Kornek, G; Schmid, R; Kotowski, U; Thurnher, D The effect of cilengitide in combination with irradiation and chemotherapy in head and neck squamous cell carcinoma cell lines.
Strahlenther Onkol. 2014; 190(5): 472-479. Doi: 10.1007/s00066-014-0600-x
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Herz, C; Hertrampf, A; Zimmermann, S; Stetter, N; Wagner, M; Kleinhans, C; Erlacher, M; Schüler, J; Platz, S; Rohn, S; Mersch-Sundermann, V; Lamy, E The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC.
J Cell Mol Med. 2014; 18(12): 2393-2403. Doi: 10.1111/jcmm.12412 [OPEN ACCESS]
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Kiesslich, T; Mayr, C; Wachter, J; Bach, D; Fuereder, J; Wagner, A; Alinger, B; Pichler, M; Di Fazio, P; Ocker, M; Berr, F; Neureiter, D Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer.
Mol Cell Biochem. 2014; 396(1-2):257-268 Doi: 10.1007/s11010-014-2161-9
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Koyani, CN; Windischhofer, W; Rossmann, C; Jin, G; Kickmaier, S; Heinzel, FR; Groschner, K; Alavian-Ghavanini, A; Sattler, W; Malle, E 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.
Int J Cardiol. 2014; 173(3):472-480 Doi: 10.1016/j.ijcard.2014.03.086 [OPEN ACCESS]
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Quan, P; Moinfar, F; Kufferath, I; Absenger, M; Kueznik, T; Denk, H; Zatloukal, K; Haybaeck, J Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling.
Anticancer Res. 2014; 34(6):2883-2897
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Schelch, K; Hoda, MA; Klikovits, T; Münzker, J; Ghanim, B; Wagner, C; Garay, T; Laszlo, V; Setinek, U; Dome, B; Filipits, M; Pirker, C; Heffeter, P; Selzer, E; Tovari, J; Torok, S; Kenessey, I; Holzmann, K; Grasl-Kraupp, B; Marian, B; Klepetko, W; Berger, W; Hegedus, B; Grusch, M Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.
Am J Respir Crit Care Med. 2014; 190(7):763-772 Doi: 10.1164/rccm.201404-0658OC
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Schneditz, G; Rentner, J; Roier, S; Pletz, J; Herzog, KA; Bücker, R; Troeger, H; Schild, S; Weber, H; Breinbauer, R; Gorkiewicz, G; Högenauer, C; Zechner, EL Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis.
Proc Natl Acad Sci U S A. 2014; 111(36):13181-13186 Doi: 10.1073/pnas.1403274111 [OPEN ACCESS]
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Veith, C; Zakrzewicz, D; Dahal, BK; Bálint, Z; Murmann, K; Wygrecka, M; Seeger, W; Schermuly, RT; Weissmann, N; Kwapiszewska, G Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
Thromb Haemost. 2014; 112(6):1288-1303 Doi: 10.1160/TH13-12-1031
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2013

Cekauskas, A; Bruns, H; Manikas, M; Herr, I; Gross, ML; Zorn, M; Jankevicius, F; Strupas, K; Schemmer, P Sulforaphane decreases kidney injury after transplantation in rats: role of mitochondrial damage.
Ann Transplant. 2013; 18(3-4):488-496 Doi: 10.12659/AOT.884013 [OPEN ACCESS]
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Fröhlich, E; Meindl, C; Höfler, A; Leitinger, G; Roblegg, E Combination of small size and carboxyl functionalisation causes cytotoxicity of short carbon nanotubes.
Nanotoxicology. 2013; 7(7):1211-1224 Doi: 10.3109/17435390.2012.729274 [OPEN ACCESS]
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