Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: TRIGLYCERIDES - METABOLISM, . Treffer: 101

2024

Hoffmann, WG; Chen, YQ; Schwartz, CS; Barber, JL; Dev, PK; Reasons, RJ; Miranda, Maravi, JS; Armstrong, B; Gerszten, RE; Silbernagel, G; Konrad, RJ; Bouchard, C; Sarzynski, MA Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits.
J Lipid Res. 2024; 65(2):100495 Doi: 10.1016/j.jlr.2023.100495 [OPEN ACCESS]
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2023

Bradić, I; Liesinger, L; Kuentzel, KB; Vujić, N; Trauner, M; Birner-Gruenberger, R; Kratky, D Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase.
J Lipid Res. 2023; 64(9):100427 Doi: 10.1016/j.jlr.2023.100427 [OPEN ACCESS]
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Hofer, P; Grabner, GF; König, M; Xie, H; Bulfon, D; Ludwig, AE; Wolinski, H; Zimmermann, R; Zechner, R; Heier, C Cooperative lipolytic control of neuronal triacylglycerol by spastic paraplegia-associated enzyme DDHD2 and ATGL.
J Lipid Res. 2023; 64(11): 100457 Doi: 10.1016/j.jlr.2023.100457 [OPEN ACCESS]
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Silbernagel, G; Chen, YQ; Rief, M; Kleber, ME; Hoffmann, MM; Stojakovic, T; Stang, A; Sarzynski, MA; Bouchard, C; März, W; Qian, YW; Scharnagl, H; Konrad, RJ Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Eur Heart J. 2023; 44(25): 2335-2345. Doi: 10.1093/eurheartj/ehad261
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2022

Goeritzer, M; Schlager, S; Kuentzel, KB; Vujić, N; Korbelius, M; Rainer, S; Kolb, D; Mussbacher, M; Salzmann, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Madreiter-Sokolowski, CT; Blass, S; Eichmann, TO; Graier, WF; Kratky, D Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Cells. 2022; 11(5): Doi: 10.3390/cells11050850 [OPEN ACCESS]
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Kanti, MM; Striessnig-Bina, I; Wieser, BI; Schauer, S; Leitinger, G; Eichmann, TO; Schweiger, M; Winkler, M; Winter, E; Lana, A; Kufferath, I; Marsh, LM; Kwapiszewska, G; Zechner, R; Hoefler, G; Vesely, PW Adipose triglyceride lipase-mediated lipid catabolism is essential for bronchiolar regeneration.
JCI Insight. 2022; 7(9): Doi: 10.1172/jci.insight.149438 [OPEN ACCESS]
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Oster, M; Galhuber, M; Krstic, J; Steinhoff, JS; Lenihan-Geels, G; Wulff, S; Kiefer, MF; Petricek, KM; Wowro, SJ; Flores, RE; Yang, N; Li, C; Meng, Y; Reinisch, I; Sommerfeld, M; Weger, S; Habisch, H; Madl, T; Schulz, TJ; Prokesch, A; Schupp, M Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
J Biol Chem. 2022; 298(9):102287 Doi: 10.1016/j.jbc.2022.102287 [OPEN ACCESS]
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2021

Grabner, GF; Xie, H; Schweiger, M; Zechner, R Lipolysis: cellular mechanisms for lipid mobilization from fat stores.
Nat Metab. 2021; 3(11): 1445-1465. Doi: 10.1038/s42255-021-00493-6
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2020

Ahi, EP; Lecaudey, LA; Ziegelbecker, A; Steiner, O; Glabonjat, R; Goessler, W; Hois, V; Wagner, C; Lass, A; Sefc, KM Comparative transcriptomics reveals candidate carotenoid color genes in an East African cichlid fish.
BMC Genomics. 2020; 21(1): 54-54. Doi: 10.1186/s12864-020-6473-8 [OPEN ACCESS]
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Kolleritsch, S; Kien, B; Schoiswohl, G; Diwoky, C; Schreiber, R; Heier, C; Maresch, LK; Schweiger, M; Eichmann, TO; Stryeck, S; Krenn, P; Tomin, T; Schittmayer, M; Kolb, D; Rülicke, T; Hoefler, G; Wolinski, H; Madl, T; Birner-Gruenberger, R; Haemmerle, G Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.
Cardiovasc Res. 2020; 116(2):339-352 Doi: 10.1093/cvr/cvz119 [OPEN ACCESS]
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2019

Pajed, L; Wagner, C; Taschler, U; Schreiber, R; Kolleritsch, S; Fawzy, N; Pototschnig, I; Schoiswohl, G; Pusch, LM; Wieser, BI; Vesely, P; Hoefler, G; Eichmann, TO; Zimmermann, R; Lass, A Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.
J Biol Chem. 2019; 294(23):9118-9133 Doi: 10.1074/jbc.RA118.007201 [OPEN ACCESS]
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Werthebach, M; Stewart, FA; Gahlen, A; Mettler-Altmann, T; Akhtar, I; Maas-Enriquez, K; Droste, A; Eichmann, TO; Poschmann, G; Stühler, K; Beller, M Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.
Cell Rep. 2019; 26(13): 3726-3740.e7. Doi: 10.1016/j.celrep.2019.02.110
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2018

Padmanabha, Das, KM; Wechselberger, L; Liziczai, M; De, la, Rosa, Rodriguez, M; Grabner, GF; Heier, C; Viertlmayr, R; Radler, C; Lichtenegger, J; Zimmermann, R; Borst, JW; Zechner, R; Kersten, S; Oberer, M Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.
J Lipid Res. 2018; 59(3): 531-541. Doi: 10.1194/jlr.M082388 [OPEN ACCESS]
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Segerer, G; Engelmann, D; Kaestner, A; Trötzmüller, M; Köfeler, H; Stigloher, C; Thiele, C; Jeanclos, E; Gohla, A A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling.
Biochim Biophys Acta. 2018; 1863(6):584-594 Doi: 10.1016/j.bbalip.2018.03.002
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2017

Grond, S; Radner, FPW; Eichmann, TO; Kolb, D; Grabner, GF; Wolinski, H; Gruber, R; Hofer, P; Heier, C; Schauer, S; Rülicke, T; Hoefler, G; Schmuth, M; Elias, PM; Lass, A; Zechner, R; Haemmerle, G Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.
J Invest Dermatol. 2017; 137(2):403-413 Doi: 10.1016/j.jid.2016.09.025 [OPEN ACCESS]
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Lindquist, C; Bjørndal, B; Rossmann, CR; Tusubira, D; Svardal, A; Røsland, GV; Tronstad, KJ; Hallström, S; Berge, RK Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats.
J Lipid Res. 2017; 58(7):1362-1373 Doi: 10.1194/jlr.M074849 [OPEN ACCESS]
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Zechner, R; Madeo, F; Kratky, D Cytosolic lipolysis and lipophagy: two sides of the same coin.
Nat Rev Mol Cell Biol. 2017; 18(11):671-684 Doi: 10.1038/nrm.2017.76
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2016

Bartuzi, P; Billadeau, DD; Favier, R; Rong, S; Dekker, D; Fedoseienko, A; Fieten, H; Wijers, M; Levels, JH; Huijkman, N; Kloosterhuis, N; van der Molen, H; Brufau, G; Groen, AK; Elliott, AM; Kuivenhoven, JA; Plecko, B; Grangl, G; McGaughran, J; Horton, JD; Burstein, E; Hofker, MH; van de Sluis, B CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Nat Commun. 2016; 7(5):10961-10961 Doi: 10.1038/ncomms10961 [OPEN ACCESS]
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Dichlberger, A; Schlager, S; Kovanen, PT; Schneider, WJ Lipid droplets in activated mast cells - a significant source of triglyceride-derived arachidonic acid for eicosanoid production.
Eur J Pharmacol. 2016; 785(2):59-69 Doi: 10.1016/j.ejphar.2015.07.020
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Fengler, VH; Macheiner, T; Kessler, SM; Czepukojc, B; Gemperlein, K; Müller, R; Kiemer, AK; Magnes, C; Haybaeck, J; Lackner, C; Sargsyan, K Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease.
PLoS One. 2016; 11(5):e0155163-e0155163 Doi: 10.1371/journal.pone.0155163 [OPEN ACCESS]
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Klein, I; Klug, L; Schmidt, C; Zandl, M; Korber, M; Daum, G; Athenstaedt, K Regulation of the yeast triacylglycerol lipases Tgl4p and Tgl5p by the presence/absence of nonpolar lipids.
Mol Biol Cell. 2016; 27(13):2014-2024 Doi: 10.1091/mbc.E15-09-0633 [OPEN ACCESS]
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Radović, B; Vujić, N; Leopold, C; Schlager, S; Goeritzer, M; Patankar, JV; Korbelius, M; Kolb, D; Reindl, J; Wegscheider, M; Tomin, T; Birner-Gruenberger, R; Schittmayer, M; Groschner, L; Magnes, C; Diwoky, C; Frank, S; Steyrer, E; Du, H; Graier, WF; Madl, T; Kratky, D Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Diabetologia. 2016; 59(8):1743-1752 Doi: 10.1007/s00125-016-3968-6 [OPEN ACCESS]
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Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Biochim Biophys Acta. 2016; 1861(9 Pt A):1132-1141 Doi: 10.1016/j.bbalip.2016.06.014 [OPEN ACCESS]
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2015

Bitter, A; Rümmele, P; Klein, K; Kandel, BA; Rieger, JK; Nüssler, AK; Zanger, UM; Trauner, M; Schwab, M; Burk, O Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
Arch Toxicol. 2015; 89(11):2089-2103 Doi: 10.1007/s00204-014-1348-x
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Boeszoermenyi, A; Nagy, HM; Arthanari, H; Pillip, CJ; Lindermuth, H; Luna, RE; Wagner, G; Zechner, R; Zangger, K; Oberer, M Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring.
J Biol Chem. 2015; 290(44):26361-26372 Doi: 10.1074/jbc.M115.682203 [OPEN ACCESS]
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Eichmann, TO; Grumet, L; Taschler, U; Hartler, J; Heier, C; Woblistin, A; Pajed, L; Kollroser, M; Rechberger, G; Thallinger, GG; Zechner, R; Haemmerle, G; Zimmermann, R; Lass, A ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6.
J Lipid Res. 2015; 56(10):1972-84 Doi: 10.1194/jlr.M062372 [OPEN ACCESS]
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Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 Doi: 10.1016/j.bbalip.2015.06.005 [OPEN ACCESS]
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Heier, C; Radner, FP; Moustafa, T; Schreiber, R; Grond, S; Eichmann, TO; Schweiger, M; Schmidt, A; Cerk, IK; Oberer, M; Theussl, HC; Wojciechowski, J; Penninger, JM; Zimmermann, R; Zechner, R G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
J Biol Chem. 2015; 290(43):26141-50 Doi: 10.1074/jbc.M115.671842 [OPEN ACCESS]
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Hofer, P; Boeszoermenyi, A; Jaeger, D; Feiler, U; Arthanari, H; Mayer, N; Zehender, F; Rechberger, G; Oberer, M; Zimmermann, R; Lass, A; Haemmerle, G; Breinbauer, R; Zechner, R; Preiss-Landl, K Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling.
J Biol Chem. 2015; 290(30):18438-18453 Doi: 10.1074/jbc.M114.628958 [OPEN ACCESS]
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Taschler, U; Schreiber, R; Chitraju, C; Grabner, GF; Romauch, M; Wolinski, H; Haemmerle, G; Breinbauer, R; Zechner, R; Lass, A; Zimmermann, R Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.
Biochim Biophys Acta. 2015; 1851(7):937-45 Doi: 10.1016/j.bbalip.2015.02.017 [OPEN ACCESS]
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2014

Brahma, MK; Adam, RC; Pollak, NM; Jaeger, D; Zierler, KA; Pöcher, N; Schreiber, R; Romauch, M; Moustafa, T; Eder, S; Ruelicke, T; Preiss-Landl, K; Lass, A; Zechner, R; Haemmerle, G Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.
J Lipid Res. 2014; 55(11):2229-2241 Doi: 10.1194/jlr.M044784 [OPEN ACCESS]
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Dichlberger, A; Schlager, S; Maaninka, K; Schneider, WJ; Kovanen, PT Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.
J Lipid Res. 2014; 55(12):2471-2478 Doi: 10.1194/jlr.M048553 [OPEN ACCESS]
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Goeritzer, M; Schlager, S; Radovic, B; Madreiter, CT; Rainer, S; Thomas, G; Lord, CC; Sacks, J; Brown, AL; Vujic, N; Obrowsky, S; Sachdev, V; Kolb, D; Chandak, PG; Graier, WF; Sattler, W; Brown, JM; Kratky, D Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
J Lipid Res. 2014; 55(12):2562-2575 Doi: 10.1194/jlr.M052613 [OPEN ACCESS]
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Nagy, HM; Paar, M; Heier, C; Moustafa, T; Hofer, P; Haemmerle, G; Lass, A; Zechner, R; Oberer, M; Zimmermann, R Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.
Biochim Biophys Acta. 2014; 1841(4):588-594 Doi: 10.1016/j.bbalip.2014.01.005 [OPEN ACCESS]
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Schrammel, A; Mussbacher, M; Wölkart, G; Stessel, H; Pail, K; Winkler, S; Schweiger, M; Haemmerle, G; Al Zoughbi, W; Höfler, G; Lametschwandtner, A; Zechner, R; Mayer, B Endothelial dysfunction in adipose triglyceride lipase deficiency.
Biochim Biophys Acta. 2014; 1841(6):906-917 Doi: 10.1016/j.bbalip.2014.03.005 [OPEN ACCESS]
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Schweiger, M; Eichmann, TO; Taschler, U; Zimmermann, R; Zechner, R; Lass, A Measurement of lipolysis.
Methods Enzymol. 2014; 538:171-93 Doi: 10.1016/B978-0-12-800280-3.00010-4 [OPEN ACCESS]
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Sparks, LM; Bosma, M; Brouwers, B; van, de, Weijer, T; Bilet, L; Schaart, G; Moonen-Kornips, E; Eichmann, TO; Lass, A; Hesselink, MKC; Schrauwen, P Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.
Diabetes. 2014; 63(5): 1583-1593. Doi: 10.2337/db13-1123 [OPEN ACCESS]
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2013

Fuchs, C; Claudel, T; Trauner, M Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342 Doi: 10.1055/s-0033-1358520
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Perathoner, A; Weißenbacher, A; Sucher, R; Laimer, E; Pratschke, J; Mittermair, R Significant weight loss and rapid resolution of diabetes and dyslipidemia during short-term follow-up after laparoscopic sleeve gastrectomy.
Obes Surg. 2013; 23(12):1966-72 Doi: 10.1007/s11695-013-1038-4
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Ploier, B; Scharwey, M; Koch, B; Schmidt, C; Schatte, J; Rechberger, G; Kollroser, M; Hermetter, A; Daum, G Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae.
J Biol Chem. 2013; 288(50):36061-36072 Doi: 10.1074/jbc.M113.509927 [OPEN ACCESS]
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Pollak, NM; Schweiger, M; Jaeger, D; Kolb, D; Kumari, M; Schreiber, R; Kolleritsch, S; Markolin, P; Grabner, GF; Heier, C; Zierler, KA; Rülicke, T; Zimmermann, R; Lass, A; Zechner, R; Haemmerle, G Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
J Lipid Res. 2013; 54(4):1092-102 Doi: 10.1194/jlr.M034710 [OPEN ACCESS]
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Radulovic, M; Knittelfelder, O; Cristobal-Sarramian, A; Kolb, D; Wolinski, H; Kohlwein, SD The emergence of lipid droplets in yeast: current status and experimental approaches.
Curr Genet. 2013; 59(4):231-242 Doi: 10.1007/s00294-013-0407-9 [OPEN ACCESS]
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Zierler, KA; Jaeger, D; Pollak, NM; Eder, S; Rechberger, GN; Radner, FP; Woelkart, G; Kolb, D; Schmidt, A; Kumari, M; Preiss-Landl, K; Pieske, B; Mayer, B; Zimmermann, R; Lass, A; Zechner, R; Haemmerle, G Functional cardiac lipolysis in mice critically depends on comparative gene identification-58.
J Biol Chem. 2013; 288(14):9892-9904 Doi: 10.1074/jbc.M112.420620 [OPEN ACCESS]
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2012

Aflaki, E; Doddapattar, P; Radovic, B; Povoden, S; Kolb, D; Vujic, N; Wegscheider, M; Koefeler, H; Hornemann, T; Graier, WF; Malli, R; Madeo, F; Kratky, D C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.
Cell Death Dis. 2012; 3(6):e280-e280 Doi: 10.1038/cddis.2012.17 [OPEN ACCESS]
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Chitraju, C; Trotzmuller, M; Hartler, J; Wolinski, H; Thallinger, GG; Lass, A; Zechner, R; Zimmermann, R; Kofeler, HC; Spener, F; Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress.
J Lipid Res. 2012; 53(10):2141-2152 Doi: 10.1194/jlr.M028902 [OPEN ACCESS]
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Fuchs, CD; Claudel, T; Kumari, P; Haemmerle, G; Pollheimer, MJ; Stojakovic, T; Scharnagl, H; Halilbasic, E; Gumhold, J; Silbert, D; Koefeler, H; Trauner, M Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.
Hepatology. 2012; 56(1):270-280 Doi: 10.1002/hep.25601 [OPEN ACCESS]
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Jaffer, I; Riederer, M; Shah, P; Peters, P; Quehenberger, F; Wood, A; Scharnagl, H; März, W; Kostner, KM; Kostner, GM Expression of fat mobilizing genes in human epicardial adipose tissue.
Atherosclerosis. 2012; 220(1): 122-127. Doi: 10.1016/j.atherosclerosis.2011.10.026
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Morak, M; Schmidinger, H; Riesenhuber, G; Rechberger, GN; Kollroser, M; Haemmerle, G; Zechner, R; Kronenberg, F; Hermetter, A Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues.
Mol Cell Proteomics. 2012; 11(12):1777-1789 Doi: 10.1074/mcp.M111.015743 [OPEN ACCESS]
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Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151 Doi: 10.1053/j.gastro.2011.09.051
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Obrowsky, S; Chandak, PG; Patankar, JV; Pfeifer, T; Povoden, S; Schreiber, R; Haemmerle, G; Levak-Frank, S; Kratky, D Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice.
Biochim Biophys Acta. 2012; 1821(11):1406-1414 Doi: 10.1016/j.bbalip.2012.07.013 [OPEN ACCESS]
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