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Richter, A.
The influence of body temperature during immediate postnatal transition on cerebral oxygenation and short-term outcome
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. 52 [OPEN ACCESS]


Authors Med Uni Graz:
Mileder Lukas Peter
Pichler Gerhard

Objective: The primary aim of this study was to investigate the potential correlation between body temperature and regional cerebral oxygen saturation (crSO2) in neonates during the first 15 minutes of life after delivery by caesarean section. Furthermore, we looked for differences in body temperature and crSO2 between term and preterm neonates and analysed, whether body temperature is associated with bacterial infection, intraventricular haemorrhage (IVH), periventricular leukomalacia or necrotizing enterocolitis (NEC). Methods: Data for this retrospective analysis were collected as part of prospective observational studies at the Division of Neonatology, Medical University of Graz. For all studies, approval by the local Ethics Committee and written parental consent prior to study inclusion were obtained. Within 15 minutes after delivery, crSO2 was measured by near-infrared spectroscopy (NIRS). In addition, the following parameters were measured/obtained: rectal body temperature in minute 15, Apgar scores in minutes 1, 5 and 10, sex, body weight, body length, head circumference, need for respiratory support or intubation, and comorbidities (early-/late onset-sepsis, IVH, periventricular leukomalacia and NEC). The data were analysed with IBM SPSS Statistics 22. Due to their distribution, data are given as median (minimum-maximum). We used non-parametric tests (Mann-Whitney-U test) for data analyses. For the correlation between rectal body temperature and crSO2, we used Spearman’s correlation. A p-value of below 0.05 was deemed statistically significant. Result: In this retrospective study 568 neonates (164 preterm and 422 term neonates) were included. The median body temperature of the whole cohort was 36.8°C (35.0-39.9). 461 of the 586 neonates (78.7%) were normothermic (body temperature 36.5-37.5°C). Median crSO2 was 78.8% (15.9-95.0) 15 minutes after birth. There was no significant correlation between body temperature and crSO2 neither for the whole group (¿=0.011, p=0.816) nor for preterm (¿=-0.071, p=0.446) or term neonates (¿=0.054, p=0.316). However, body temperature was significantly lower in preterm neonates with a mean difference of 0.1°C (p=0.003). crSO2 did not differ between groups (p=0.689). In addition, there were no differences in body temperature between neonates with comorbidities and those without. Conclusion: There was no correlation between rectally measured body temperature and crSO2 in preterm and term neonates during postnatal transition. While there was a significant difference in body temperature between preterm and term neonates, there was none in crSO2. Postnatal body temperature was not different between patients who developed bacterial infection, IVH, periventricular leukomalacia or NEC and those who did not.

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