Medizinische Universität Graz - Research portal
Selected Publication:
Reisinger, J.
Characterization of organ quality of donation after cardiac death, brain-dead donors and living donors. A review of current literature
[ Diplomarbeit ] Medical University of Graz; 2013. pp. 60
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- Authors Med Uni Graz:
- Advisor:
- Sereinigg Michael
- Stadlbauer-Köllner Vanessa
- Stiegler Philipp
- Altmetrics:
- Abstract:
- For patients with diseases leading to irreversible organ failure, transplantation is the therapy and the chance for a new life. To combat the shortage of organs and to have a larger pool of donors available, it falls back to DCD and always more marginal donors. Still marginal donor organs are providing poorer results after transplantation. Ischemic and reperfusion damage occur in donor organs. ROS or RNS formation lead to a change in gene or protein expression. Changes caused by ischemia/reperfusion affect genes leading to apoptosis. Therefore, a strong ischemia/reperfusion injury ends up in apoptosis and lower functioning cell mass in the donor organ, which affects the function and the result in the recipient. In order to measure the body and to improve quality subsequently, primers such as Bcl-2, Bax, GSH, GPx (Gpx3), OXSR-1, NF-¿B, SOD (SOD2), Heat Shock proteins (Hsp70), PPAR¿, HPRT, Nitrotyrosine (3-NT), Myeloperoxidase (MPO) and Caspase-3 are measured. In summary, can be said that Bax, NF-¿B, MPO, 3-NT and Caspase-3 are up regulated in ischemia and determine worse results or lead to apoptosis. Other genes and proteins, such as Bcl-2, GSH, GPx-3, OXSR-1, NF-¿B, SOD2, Hsp70, PPAR¿, HPRT-1 have protective properties.