Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Smolle, MA; Leithner, A; Posch, F; Szkandera, J; Liegl-Atzwanger, B; Pichler, M.
MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review.
Int J Mol Sci. 2017; 18(9):
Doi: 10.3390/ijms18091960
[OPEN ACCESS]
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Pichler Martin
- Smolle Maria Anna
- Co-authors Med Uni Graz
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Posch Florian
- Szkandera Joanna
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- Abstract:
- Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor -
- Fibrosarcoma - metabolism
- Gene Expression Regulation, Neoplastic -
- Hemangiosarcoma - metabolism
- Humans -
- Leiomyosarcoma - metabolism
- Liposarcoma - metabolism
- MicroRNAs - classification
- MicroRNAs - genetics
- MicroRNAs - metabolism
- Neurilemmoma - metabolism
- Prognosis -
- RNA, Messenger - genetics
- Rhabdomyosarcoma - metabolism
- Sarcoma - diagnosis
- Sarcoma - genetics
- Sarcoma - metabolism
- Sarcoma, Synovial - metabolism
- Find related publications in this database (Keywords)
- soft tissue sarcoma
- microRNAs
- tumourigenesis