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Smolle, MA; Leithner, A; Posch, F; Szkandera, J; Liegl-Atzwanger, B; Pichler, M.
MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review.
Int J Mol Sci. 2017; 18(9): Doi: 10.3390/ijms18091960 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Leading authors Med Uni Graz
Pichler Martin
Smolle Maria Anna
Co-authors Med Uni Graz
Leithner Andreas
Liegl-Atzwanger Bernadette
Posch Florian
Szkandera Joanna
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Abstract:
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
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Find related publications in this database (Keywords)
soft tissue sarcoma
microRNAs
tumourigenesis
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