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SHR Neuro Cancer Cardio Lipid

Klec, C; Ziomek, G; Pichler, M; Malli, R; Graier, WF.
Calcium Signaling in ß-cell Physiology and Pathology: A Revisit.
Int J Mol Sci. 2019; 20(24): [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Authors Med Uni Graz:
Graier Wolfgang
Klec Christiane
Malli Roland
Pichler Martin
Ziomek Gabriela
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Abstract:
Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed regulation of blood glucose levels. This forms the backbone of the development of diabetes mellitus (DM), a disease that affects a significant portion of the global adult population. Physiological calcium (Ca2+) signaling has been found to be vital for the proper insulin-releasing function of β-cells. Calcium dysregulation events can have a dramatic effect on the proper functioning of the pancreatic β-cells. The current review discusses the role of calcium signaling in health and disease in pancreatic β-cells and provides an in-depth look into the potential role of alterations in β-cell Ca2+ homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium and the onset of diabetes.

Find related publications in this database (Keywords)
beta-cells
Ca2+ signaling
insulin secretion
diabetes
mitochondria
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