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Fahrleitner-Pammer, A; Dobnig, H; Dimai, HP; Holzer, H; Benesch, T; Borchhardt, K; Cejka, D; Haas, M.
The effect of RANKL and OPG on bone mineral density in pre-dialysis chronic renal failure.
Clin Nephrol. 2009; Volume 71(June): 652-659. Doi: 10.5414/CNP71652
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Leading authors Med Uni Graz
Fahrleitner-Pammer Astrid
Co-authors Med Uni Graz
Dimai Hans Peter
Dobnig Harald
Holzer Herwig
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Abstract:
Aims: The influence of pre-dialysis chronic kidney disease (CKD) on bone is ill defined. Isolation of specific pathogenic mechanisms would improve the understanding and therapeutic options. We therefore investigated whether parathyroid dysfunction, altered vitamin D and hormonal status, or RANKL and OPG have an influence on bone mineral density (BMD) in patients with pre-dialysis renal failure. Material: 132 patients with chronic renal failure stage 1-5 (not yet on dialysis) were investigated in a cross sectional study. Osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), parathyroid hormone (whole, intact and 7-84 fragment), bone markers, sex hormones, and vitamin D status were assessed together with femoral neck and trochanter z-score. Correlation and multivariate analyses were performed between the different parameters and BMD. Results: In the multivariate analysis a significant association was found between the femoral neck z-score and sRANKL (B = -0.45; p < 0.001), and OPG (B = 0.20; p < 0.05). A significant negative association was also found between the trochanter z-score and sRANKL (B = -0.32; p < 0.001). No associations were found between the trochanter z-score and OPG or the sRANKL/OPG ratio. The body mass index was the only additional marker associated with both FN z-score (B = 0.20, p < 0.05) and TR z-score (B = 0.20, p < 0.05). Neither markers of osteoblast nor osteoclast activity, or intact PTH, whole PTH, the PTH 7-84 fragment or vitamin D status were related to bone mineral density. Conclusion: Our results demonstrate that the RANKL/RANK/OPG system is associated with bone mineral density in pre-dialysis chronic renal failure.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Biological Markers -
Body Mass Index -
Bone Density -
Cross-Sectional Studies -
Female -
Femur - physiopathology
Follicle Stimulating Hormone - blood
Glomerular Filtration Rate -
Humans -
Kidney Failure, Chronic - blood
Luteinizing Hormone - blood
Male -
Middle Aged -
Osteoprotegerin - blood
Parathyroid Hormone - metabolism
RANK Ligand - blood
Testosterone - blood
Vitamin D - blood

Find related publications in this database (Keywords)
OPG
RANK
RANKL
bone mineral density
chronic renal failure
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