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Fahrleitner-Pammer, A; Dobnig, H; Dimai, HP; Holzer, H; Benesch, T; Borchhardt, K; Cejka, D; Haas, M.
The effect of RANKL and OPG on bone mineral density in pre-dialysis chronic renal failure.
Clin Nephrol. 2009; Volume 71(June): 652-659. Doi: 10.5414/CNP71652
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Leading authors Med Uni Graz: Fahrleitner-Pammer Astrid
Co-authors Med Uni Graz: Dimai Hans Peter; Dobnig Harald; Holzer Herwig
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Abstract:: Aims: The influence of pre-dialysis chronic kidney disease (CKD) on bone is ill defined. Isolation of specific pathogenic mechanisms would improve the understanding and therapeutic options. We therefore investigated whether parathyroid dysfunction, altered vitamin D and hormonal status, or RANKL and OPG have an influence on bone mineral density (BMD) in patients with pre-dialysis renal failure. Material: 132 patients with chronic renal failure stage 1-5 (not yet on dialysis) were investigated in a cross sectional study. Osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), parathyroid hormone (whole, intact and 7-84 fragment), bone markers, sex hormones, and vitamin D status were assessed together with femoral neck and trochanter z-score. Correlation and multivariate analyses were performed between the different parameters and BMD. Results: In the multivariate analysis a significant association was found between the femoral neck z-score and sRANKL (B = -0.45; p < 0.001), and OPG (B = 0.20; p < 0.05). A significant negative association was also found between the trochanter z-score and sRANKL (B = -0.32; p < 0.001). No associations were found between the trochanter z-score and OPG or the sRANKL/OPG ratio. The body mass index was the only additional marker associated with both FN z-score (B = 0.20, p < 0.05) and TR z-score (B = 0.20, p < 0.05). Neither markers of osteoblast nor osteoclast activity, or intact PTH, whole PTH, the PTH 7-84 fragment or vitamin D status were related to bone mineral density. Conclusion: Our results demonstrate that the RANKL/RANK/OPG system is associated with bone mineral density in pre-dialysis chronic renal failure.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Biological Markers -; Body Mass Index -; Bone Density -; Cross-Sectional Studies -; Female -; Femur - physiopathology; Follicle Stimulating Hormone - blood; Glomerular Filtration Rate -; Humans -; Kidney Failure, Chronic - blood; Luteinizing Hormone - blood; Male -; Middle Aged -; Osteoprotegerin - blood; Parathyroid Hormone - metabolism; RANK Ligand - blood; Testosterone - blood; Vitamin D - blood
Find related publications in this database (Keywords): OPG; RANK; RANKL; bone mineral density; chronic renal failure