Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Lemesch, S; Ribitsch, W; Schilcher, G; Spindelböck, W; Hafner-Gießauf, H; Marsche, G; Pasterk, L; Payerl, D; Schmerböck, B; Tawdrous, M; Rosenkranz, AR; Stiegler, P; Kager, G; Hallström, S; Oettl, K; Eberhard, K; Horvath, A; Leber, B; Stadlbauer, V.
Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease.
Sci Rep. 2016; 6(6):34534-34534 Doi: 10.1038/srep34534 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Lemesch Sandra
Ribitsch Werner
Co-authors Med Uni Graz
Eberhard Katharina
Hafner-Giessauf Hildegard Elisabeth
Hallström Seth
Horvath Angela
Kager Gerd
Leber Bettina
Marsche Gunther
Öttl Karl
Pasterk Lisa
Payerl Doris
Rosenkranz Alexander
Schilcher Gernot
Spindelböck Walter Johann
Stadlbauer-Köllner Vanessa
Stiegler Philipp
Tawdrous Monika

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Bacterial infection and sepsis are common complications of chronic kidney disease (CKD). A vicious cycle of increased gut permeability, endotoxemia, inadequate activation of the innate immune system and resulting innate immune dysfunction is hypothesized. We assessed endotoxemia, neutrophil function and its relation to oxidative stress, inflammation and gut permeability in patients with CKD grade 3-5 without renal replacement therapy (CKD group, n = 57), patients with CKD stage 5 undergoing haemodialysis (HD, n = 32) or peritoneal dialysis (PD, n = 28) and patients after kidney transplantation (KT, n = 67) in a cross-sectional observational study. In HD patients, endotoxin serum levels were elevated and neutrophil phagocytic capacity was decreased compared to all other groups. Patients on HD had a significantly higher mortality, due to infections during follow up, compared to PD (p = 0.022). Oxidative stress, neutrophil energy charge, systemic inflammation and gut permeability could not completely explain these differences. Our findings suggest that dialysis modality and not renal function per se determine the development of neutrophil dysfunction and endotoxemia in CKD-patients. HD patients are particularly prone to neutrophil dysfunction and endotoxemia whereas neutrophil function seems to improve after KT. Multi-target approaches are therefore warranted to improve neutrophil function and potentially reduce the rate of infections with patients undergoing haemodialysis.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Bacterial Infections - blood
Bacterial Infections - etiology
Bacterial Infections - mortality
Bacterial Infections - therapy
Cross-Sectional Studies -
Endotoxemia - blood
Endotoxemia - etiology
Endotoxemia - mortality
Endotoxemia - pathology
Female -
Humans -
Male -
Middle Aged -
Neutrophils - metabolism
Neutrophils - pathology
Oxidative Stress -
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - therapy
Renal Replacement Therapy -

© Med Uni GrazImprint