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SHR Neuro Cancer Cardio Lipid Metab Microb

Krause, R; Halwachs, B; Thallinger, GG; Klymiuk, I; Gorkiewicz, G; Hoenigl, M; Prattes, J; Valentin, T; Heidrich, K; Buzina, W; Salzer, HJ; Rabensteiner, J; Prüller, F; Raggam, RB; Meinitzer, A; Moissl-Eichinger, C; Högenauer, C; Quehenberger, F; Kashofer, K; Zollner-Schwetz, I.
Characterisation of Candida within the Mycobiome/Microbiome of the Lower Respiratory Tract of ICU Patients.
PLoS One. 2016; 11(5):e0155033-e0155033 Doi: 10.1371/journal.pone.0155033 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Krause Robert
Co-authors Med Uni Graz
Buzina Walter
Gorkiewicz Gregor
Halwachs-Wenzl Bettina
Hoegenauer Christoph
Hönigl Martin
Kashofer Karl
Klymiuk Ingeborg
Meinitzer Andreas
Moissl-Eichinger Christine
Prattes Jürgen
Prüller Florian
Quehenberger Franz
Rabensteiner Jasmin
Raggam Reinhard Bernd
Salzer Helmut J. F.
Valentin Thomas
Zollner-Schwetz Ines

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Whether the presence of Candida spp. in lower respiratory tract (LRT) secretions is a marker of underlying disease, intensive care unit (ICU) treatment and antibiotic therapy or contributes to poor clinical outcome is unclear. We investigated healthy controls, patients with proposed risk factors for Candida growth in LRT (antibiotic therapy, ICU treatment with and without antibiotic therapy), ICU patients with pneumonia and antibiotic therapy and candidemic patients (for comparison of truly invasive and colonizing Candida spp.). Fungal patterns were determined by conventional culture based microbiology combined with molecular approaches (next generation sequencing, multilocus sequence typing) for description of fungal and concommitant bacterial microbiota in LRT, and host and fungal biomarkes were investigated. Admission to and treatment on ICUs shifted LRT fungal microbiota to Candida spp. dominated fungal profiles but antibiotic therapy did not. Compared to controls, Candida was part of fungal microbiota in LRT of ICU patients without pneumonia with and without antibiotic therapy (63% and 50% of total fungal genera) and of ICU patients with pneumonia with antibiotic therapy (73%) (p<0.05). No case of invasive candidiasis originating from Candida in the LRT was detected. There was no common bacterial microbiota profile associated or dissociated with Candida spp. in LRT. Colonizing and invasive Candida strains (from candidemic patients) did not match to certain clades withdrawing the presence of a particular pathogenic and invasive clade. The presence of Candida spp. in the LRT rather reflected rapidly occurring LRT dysbiosis driven by ICU related factors than was associated with invasive candidiasis.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Anti-Bacterial Agents - therapeutic use
Candida - classification
Candida - drug effects
Candida - genetics
Candida - pathogenicity
Candidiasis - diagnosis
Candidiasis - drug therapy
Female -
High-Throughput Nucleotide Sequencing -
Humans -
Intensive Care Units - statistics & numerical data
Male -
Microbiota - physiology
Middle Aged -
Mouth - microbiology
Mycobiome - physiology
Phylogeny -
Pneumonia - drug therapy
Pneumonia - microbiology
Respiratory System - microbiology
Risk Factors -

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