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SHR Neuro Cancer Cardio Lipid Metab Microb

Szkandera, J; Pichler, M; Liegl-Atzwanger, B; Absenger, G; Stotz, M; Ploner, F; Stojakovic, T; Samonigg, H; Eberhard, K; Leithner, A; Gerger, A.
The elevated pre-operative plasma fibrinogen level is an independent negative prognostic factor for cancer-specific, disease-free and overall survival in soft-tissue sarcoma patients.
J Surg Oncol. 2014; 109(2):139-144 Doi: 10.1002/jso.23458
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Leading authors Med Uni Graz
Pichler Martin
Szkandera Joanna
Co-authors Med Uni Graz
Absenger Gudrun
Eberhard Katharina
Gerger Armin
Leithner Andreas
Liegl-Atzwanger Bernadette
Ploner Ferdinand
Samonigg Hellmut
Stojakovic Tatjana
Stotz Michael

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Accumulating evidence indicates an important pathophysiological role of fibrinogen on tumor cell progression and metastases in different types of cancer. The aim of the present study was to evaluate the prognostic relevance of pre-operative fibrinogen levels on clinical outcome in a large cohort of STS patients. Two hundred ninety-four consecutive STS patients were retrospectively evaluated. Cancer-specific survival (CSS), disease-free survival (DFS), and overall survival (OS) were assessed using the Kaplan-Meier curves and Cox regression models. Finally, we supplemented the well-established Kattan nomogram by the fibrinogen level and evaluated the gain of predictive accuracy of this novel nomogram by Harrell's concordance index (c-index). An elevated plasma fibrinogen level was significantly associated with established prognostic factors, including age, tumor grade, size, and depth (P<0.05). Furthermore, in multivariate analysis, increased fibrinogen levels were significantly associated with a poor outcome for CSS (HR=2.48; 95% CI=1.28-4.78; P=0.007), DFS (HR=2.00; 95% CI=1.11-3.60; P=0.021), and OS (HR=2.20; 95% CI=1.39-3.47; P<0.001). The estimated c-index was 0.747 using the original Kattan nomogram and 0.779 when the fibrinogen levels was added. The pre-operative plasma fibrinogen level may represent a strong and independent unfavorable prognostic factor for CSS, DFS and OS in STS patients. © 2013 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Biomarkers, Tumor - blood
Disease Progression -
Disease-Free Survival -
Female -
Fibrinogen - metabolism
Follow-Up Studies -
Humans -
Male -
Middle Aged -
Neoplasm Grading -
Nomograms -
Preoperative Care -
Prognosis -
Retrospective Studies -
Sarcoma - blood
Sarcoma - mortality
Sarcoma - pathology
Sarcoma - surgery
Survival Rate -

Find related publications in this database (Keywords)
plasma fibrinogen level
soft-tissue sarcoma
prognostic factor
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