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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Szkandera, J; Pichler, M; Liegl-Atzwanger, B; Absenger, G; Stotz, M; Ploner, F; Stojakovic, T; Samonigg, H; Eberhard, K; Leithner, A; Gerger, A.
The elevated pre-operative plasma fibrinogen level is an independent negative prognostic factor for cancer-specific, disease-free and overall survival in soft-tissue sarcoma patients.
J Surg Oncol. 2014; 109(2):139-144
Doi: 10.1002/jso.23458
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Pichler Martin
- Szkandera Joanna
- Co-authors Med Uni Graz
- Absenger Gudrun
- Eberhard Katharina
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Ploner Ferdinand
- Samonigg Hellmut
- Stojakovic Tatjana
- Stotz Michael
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- Abstract:
- Accumulating evidence indicates an important pathophysiological role of fibrinogen on tumor cell progression and metastases in different types of cancer. The aim of the present study was to evaluate the prognostic relevance of pre-operative fibrinogen levels on clinical outcome in a large cohort of STS patients. Two hundred ninety-four consecutive STS patients were retrospectively evaluated. Cancer-specific survival (CSS), disease-free survival (DFS), and overall survival (OS) were assessed using the Kaplan-Meier curves and Cox regression models. Finally, we supplemented the well-established Kattan nomogram by the fibrinogen level and evaluated the gain of predictive accuracy of this novel nomogram by Harrell's concordance index (c-index). An elevated plasma fibrinogen level was significantly associated with established prognostic factors, including age, tumor grade, size, and depth (P<0.05). Furthermore, in multivariate analysis, increased fibrinogen levels were significantly associated with a poor outcome for CSS (HR=2.48; 95% CI=1.28-4.78; P=0.007), DFS (HR=2.00; 95% CI=1.11-3.60; P=0.021), and OS (HR=2.20; 95% CI=1.39-3.47; P<0.001). The estimated c-index was 0.747 using the original Kattan nomogram and 0.779 when the fibrinogen levels was added. The pre-operative plasma fibrinogen level may represent a strong and independent unfavorable prognostic factor for CSS, DFS and OS in STS patients. © 2013 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - blood
- Disease Progression -
- Disease-Free Survival -
- Female -
- Fibrinogen - metabolism
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Neoplasm Grading -
- Nomograms -
- Preoperative Care -
- Prognosis -
- Retrospective Studies -
- Sarcoma - blood
- Sarcoma - mortality
- Sarcoma - pathology
- Sarcoma - surgery
- Survival Rate -
- Find related publications in this database (Keywords)
- plasma fibrinogen level
- soft-tissue sarcoma
- prognostic factor