Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Herbert, MK; Holzer, P.
Nitric oxide mediates the amplification by interleukin-1 beta of neurogenic vasodilatation in the rat skin.
EUR J PHARMACOL 1994 260: 89-93.
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Autor/innen der Med Uni Graz:
Herbert Michael K.
Holzer Peter
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Abstract:
Blood flow in the plantar hindpaw skin of anaesthetized rats was measured by laser Doppler flowmetry. Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram). Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta. Blockade of nitric oxide formation by NG-nitro-L-arginine methyl ester failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by interleukin-1 beta. These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Arginine - analogs and derivatives
Capsaicin - pharmacology
Female - pharmacology
Humans - pharmacology
Interleukin-1 - pharmacology
NG-Nitroarginine Methyl Ester - pharmacology
Neurons, Afferent - drug effects
Nitric Oxide - antagonists and inhibitors
Rats - antagonists and inhibitors
Rats, Sprague-Dawley - antagonists and inhibitors
Regional Blood Flow - drug effects
Research Support, Non-U.S. Gov't - drug effects
Skin - blood supply
Vasodilation - drug effects

Find related publications in this database (Keywords)
Afferent Nerve Stimulation
Capsaicin
Cutaneous Hyperemia
Interleukin-1-Beta
Neurogenic Inflammation
Nitric Oxide (No)
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