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Gewählte Publikation:

Urlesberger, B; Pichler, G; Gradnitzer, E; Reiterer, F; Zobel, G; Müller, W.
Changes in cerebral blood volume and cerebral oxygenation during periodic breathing in term infants.
Neuropediatrics. 2000; 31(2):75-81 Doi: 10.1055%2Fs-2000-7477
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Führende Autor*innen der Med Uni Graz
Urlesberger Berndt
Co-Autor*innen der Med Uni Graz
Müller Wilhelm
Pichler Gerhard
Reiterer Friedrich
Zobel Gerfried

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The present study is an analysis of changes in cerebral oxygenation and cerebral blood volume (CBV) during periodic breathing in healthy term infants by means of near infrared spectroscopy (NIRS). Polygraphy included electrocardiogram, electrooculogram, heart rate, oxygen saturation, side stream capnography, two respiratory effort sensors, a movement sensor, and NIRS. During periodic breathing analysis of behaviour of total haemoglobin (cHbtot), deltaCBV, the haemoglobin oxygenation index (cHbD), and cytochrome oxidase (CytOx) was performed. In ten healthy term infants 30 cycles of periodic breathing with a mean of 10 apnoeas per cycle were analysed. Corresponding cyclical variations of cHbD appeared in 98%, cyclical variations of cHbtot appeared in 42% of all apnoeas. During phases of apnoea, a mean decrease of cHbD of -3.45 micromol/l occurred 1.75 seconds after onset of apnoea, and a mean decrease of cHbtot of -0.79 micromol/occurred 0.74 seconds after onset of apnoea. During these apnoeas, the deltaCBV was -44 microl/100 g brain. During phases of ventilation, there was an increase of cHbD and cHbtot to the pre-apnoeic levels. There was a tendency that CytOx values decreased during periodic breathing, the amount of decrease was -0.32 micromol/l. In conclusion, the present study was able to show for the first time that there is cyclical desaturation and reoxygenation of cerebral blood during periodic breathing. Cyclical changes in CBV in association with periodic apnoea occurred only in 42% of apnoea.
Find related publications in this database (using NLM MeSH Indexing)
Anoxia - physiopathology
Blood Volume - physiology
Brain - blood supply
Electron Transport Complex IV - blood
Hemoglobinometry - blood
Humans - blood
Infant - blood
Infant, Newborn - blood
Oxygen Consumption - physiology
Periodicity - physiology
Polysomnography - physiology
Reference Values - physiology
Regional Blood Flow - physiology
Retrospective Studies - physiology
Sleep Apnea, Central - physiopathology
Spectroscopy, Near-Infrared - physiopathology

Find related publications in this database (Keywords)
periodic breathing
cerebral blood volume
cerebral oxygenation
near-infrared spectroscopy
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