Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Jakubauskas, M; Jakubauskiene, L; Leber, B; Horvath, A; Strupas, K; Stiegler, P; Schemmer, P.
Probiotic Supplementation Suppresses Tumor Growth in an Experimental Colorectal Cancer Liver Metastasis Model.
INT J MOL SCI. 2022; 23(14): 7674 Doi: 10.3390/ijms23147674 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz

Stiegler Philipp

Co-Autor*innen der Med Uni Graz

Horvath Angela

Leber Bettina

Schemmer Peter

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Colorectal cancer (CRC) ranks third in incidence and second in mortality of all cancers worldwide. At the time of primary diagnosis, around 20% of patients already have metastatic CRC and only around 20% are candidates for radical resection. Thus, most of the patients have to undergo chemotherapy (CTx). Due to chemoresistance and side effects, novel treatment additives are crucial for controlling the disease and prolonging patient survival. The aim of this study was to evaluate probiotic supplementation and its antitumorigenic effects in an experimental CRC liver metastasis model. Six-week-old male Wistar rats received either a multispecies probiotic (1.2 × 10⁹ CFU/daily) or placebo mixture. On day 14 of the experiment, rat CRC cells (CC531) were implanted under the liver capsule later treated by FOLFOX CTx. Change in tumor volume was measured by performing micro computed tomography (micro-CT) scanning on experimental days 28 and 34. Additionally, immunohistochemical staining with anti-MPO, anti-Ki67, and anti-CD31 were performed. Tumor apoptosis was evaluated using TUNEL staining. Micro-CT image analysis indicates that probiotic supplementation significantly inhibits tumor growth. No synergistic effects between probiotic supplementation and FOLFOX CTx was observed. Reduced tumor volume was achieved by inhibiting angiogenesis, as tumor microvascular density was significantly lower in rats receiving probiotic supplementation. This study shows that a multispecies probiotic mixture significantly reduces angiogenesis and inhibits CRC liver metastasis growth in an experimental rat model.

Find related publications in this database (using NLM MeSH Indexing)

Animals - administration & dosage

Colorectal Neoplasms - diagnostic imaging, drug therapy, pathology

Disease Models, Animal - administration & dosage

Liver Neoplasms - diagnostic imaging, drug therapy, secondary

Male - administration & dosage

Neovascularization, Pathologic - administration & dosage

Probiotics - pharmacology

Rats - administration & dosage

Rats, Wistar - administration & dosage

Treatment Outcome - administration & dosage

X-Ray Microtomography - administration & dosage

Find related publications in this database (Keywords)

probiotics

colorectal cancer

liver metastasis

tumor suppression

© Med Uni Graz • Impressum