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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Queissner, R; Pilz, R; Dalkner, N; Birner, A; Bengesser, SA; Platzer, M; Fellendorf, FT; Kainzbauer, N; Herzog-Eberhard, S; Hamm, C; Reininghaus, B; Zelzer, S; Mangge, H; Mansur, RB; McIntyre, RS; Kapfhammer, HP; Reininghaus, EZ.
The relationship between inflammatory state and quantity of affective episodes in bipolar disorder.
Psychoneuroendocrinology. 2018; 90:61-67 Doi: 10.1016/j.psyneuen.2018.01.024
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Führende Autor*innen der Med Uni Graz

Pilz Rene

Queissner Robert

Co-Autor*innen der Med Uni Graz

Bengesser Susanne

Birner Armin

Dalkner Nina

Fellendorf Frederike

Hamm Carlo

Herzog-Eberhard Simone

Kainzbauer Nora

Kapfhammer Hans-Peter

Mangge Harald

Platzer Martina

Reininghaus Bernd

Reininghaus Eva

Zelzer Sieglinde

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Abstract:

Immunological/inflammatory processes have been proposed to play an important role in the pathophysiology of mood disorders, including bipolar disorder (BD). The present study aimed to examine the influence of immune activation, measured on the basis of inflammatory markers, on the course of illness, proxied by the number of affective episodes, in patients with BD. We investigated the relationship between high-sensitive CRP (hsCRP) and Interleukin 6 (IL-6), two inflammatory markers and characteristics of course of illness (e.g. number of affective episodes, depressive and manic symptoms) amongst a group of 190 individuals with BD. Among females with BD, there was a positive correlation between levels of hsCRP and the number of manic and depressive episodes. Moreover, levels of hsCRP and IL-6 were positively correlated with current manic symptoms, as measured by Young-Mania-Rating-Scale. There were no significant correlations between levels of the foregoing inflammatory markers, and manic and depressive symptoms in male individuals with BD. Furthermore, compared to their untreated counterparts, female patients treated with lithium demonstrated higher levels of hsCRP and male patients treated with atypical antipsychotics lower levels of hsCRP, respectively. Our results are suggesting that the association between inflammatory state and affective response in patients with BD may be gender-dependent. A future research would be to evaluate whether or not these gender differences can be observed in other inflammatory pathways associated with BD. Copyright © 2018 Elsevier Ltd. All rights reserved.

Find related publications in this database (Keywords)

Bipolar affective disorder

Chronic mild inflammation

Gender differences

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