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SHR Neuro Krebs Kardio Lipid

Pichler, G; Pux, C; Babeluk, R; Hermann, B; Stoiser, E; De Campo, A; Grisold, A; Zollner-Schwetz, I; Krause, R; Schippinger, W.
MRSA prevalence rates detected in a tertiary care hospital in Austria and successful treatment of MRSA positive patients applying a decontamination regime with octenidine.
Eur J Clin Microbiol Infect Dis. 2018; 37(1):21-27 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
DeCampo Antonella
Grisold Andrea
Krause Robert
Zollner-Schwetz Ines

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Methicillin-resistant Staphylococcus aureus (MRSA) decontamination regimens predominantly use chlorhexidine bathing in combination with mupirocin nasal ointment. However, resistances in Staphylococcus aureus strains are increasingly common and there is a need of alternative, safe and feasible protocols. This interventional cohort study performed at the Albert Schweitzer Hospital in Graz, Austria, aimed to (1) determine MRSA prevalence at different body sites and (2) assess the efficacy of the decontamination using octenidine-based leave-on products added to existing robust infection control measures. All inpatients of this tertiary care hospital being treated in geriatric medical wards (GWs) and apallic care units (ACUs) were screened for MRSA and decontamination rates were determined after one, two or three decontamination cycles, respectively. At baseline, MRSA was detected in 25 of the 126 patients screened (19.8%). We found MRSA in 13/126 (10.3%) swabs from nasal vestibules, in 12/126 (9.5%) skin swabs, in 11/51 (21.6%) swabs from PEG-stomata or suprapubic catheters and in 8/13 (61.5%) tracheostomata swabs. A maximum of three 5-day decontamination cycles reduced the number of MRSA positive patients by 68.0%. Excluding non-compliant and deceased patients, decontamination reduced MRSA carriage by 93.3% (n = 15). No adverse events related to the applied decontamination regimen occurred. Exclusive screening of the nose might underreport MRSA prevalence rates. In this study, decontamination with octenidine-based leave-on products was safe and effective in a critical patient population.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Anti-Bacterial Agents - therapeutic use
Austria - epidemiology
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Carrier State - microbiology
Cohort Studies -
Disinfection - methods
Female -
Humans -
Male -
Methicillin-Resistant Staphylococcus aureus - drug effects
Middle Aged -
Nasal Cavity - microbiology
Penicillin-Binding Proteins - biosynthesis
Penicillin-Binding Proteins - genetics
Pyridines - therapeutic use
Skin - microbiology
Staphylococcal Infections - diagnosis
Staphylococcal Infections - drug therapy
Staphylococcal Infections - epidemiology
Tertiary Care Centers -
Trachea - microbiology
Urinary Catheters - microbiology

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