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"Faces" of the day:

Christina Flucher

Nicole Golob-Schwarzl

Saskia Hankel

Birgit Gallé

Aaroh Anand Joshi

Qishun Zhou

Vijaykumar Patra

Mario Scherkl

Benjamin Michel Rene Bourgeois

Sebastian Tschauner

Thomas Eichmann

Gabor Toth-Gayor

Niels Hammer

Tobias Madl

Georg Singer

Human-Friedrich Unterrainer

Harald Köfeler

Roland Malli

Gernot Reishofer

Slave Trajanoski

Peter Wolf

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Herz, CT; Kulterer, OC; Prager, M; Marculescu, R; Prager, G; Kautzky-Willer, A; Hacker, M; Trajanoski, S; Köfeler, HC; Gallé, B; Haug, AR; Berry, D; Kiefer, FW.
Bariatric surgery promotes recruitment of brown fat linked to alterations in the gut microbiota.
Eur J Endocrinol. 2025; 192(5):603-611 Doi: 10.1093/ejendo/lvaf081
PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Gallé Birgit; Köfeler Harald; Trajanoski Slave
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Abstract:: OBJECTIVE: The mechanisms of bariatric surgery-induced weight loss and metabolic improvements are still incompletely understood and reach beyond malabsorption or calorie restriction. We sought to investigate the effect of bariatric surgery on brown adipose tissue (BAT) activity and a potential connection with changes in energy metabolism, the gut microbiota, and short-chain fatty acid (SCFA) composition. METHODS: We included 32 subjects (25 females) with morbid obesity and analyzed their metabolic profile, gut microbiota composition, circulating SCFAs, energy expenditure, and cold-induced BAT activity using [18F]Fluorodeoxyglucose-positron emission tomography-computed tomography before and up to 1 year after bariatric surgery. RESULTS: Twelve months after surgery, the percentage of individuals with active BAT had increased from 28% to 53%. The BAT-negative (BATneg) individuals who had an adverse metabolic profile at baseline compared with subjects with active BAT (BATpos) showed a greater metabolic benefit after surgery. While no changes in overall gut bacterial diversity were observed between BATpos and BATneg, the abundance of 3 specific bacterial families, including Akkermansiaceae, Pasteurellaceae, and Carnobacteriaceae, was distinctly regulated between BAT groups. The bacterial genera most strongly increased in BATpos vs BATneg subjects were all positively correlated with BAT volume and BAT activity. Finally, circulating concentrations of the SCFAs acetate, butyrate, and propionate rose after bariatric surgery and were related to bacterial genera such as Akkermansia, Dialister, and Lachnospiraceae FCS020 group, all known SCFA producers. CONCLUSIONS: Bariatric surgery helps recruit active BAT in individuals with obesity and is linked to distinct alterations in the gut microbiome and SCFA composition. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT03168009).
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Gastrointestinal Microbiome - physiology; Adipose Tissue, Brown - metabolism, diagnostic imaging; Female - administration & dosage; Bariatric Surgery - administration & dosage; Male - administration & dosage; Middle Aged - administration & dosage; Adult - administration & dosage; Obesity, Morbid - surgery, metabolism, microbiology; Fatty Acids, Volatile - metabolism, blood; Positron Emission Tomography Computed Tomography - administration & dosage; Energy Metabolism - physiology; Weight Loss - physiology