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SHR Neuro Cancer Cardio Lipid Metab Microb
Schwingenschlögl-Maisetschläger, V; Vila, XM; Duman, I; Okuducu, C; Kuess, P; Hacker, M; Kraule, C; Teuschl-Woller, A; Pichler, V.
Sustainable and standardized fabrication, recycling, and sterilization of salt-bed casted silk fibroin sponges.
Int J Biol Macromol. 2025; 312:144212
Doi: 10.1016/j.ijbiomac.2025.144212
PubMed
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- Co-authors Med Uni Graz
- Okuducu Ceren
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- Abstract:
- Silk fibroin, as a highly versatile biomaterial, is increasingly applied in research, medicine and other sterile applications. The rising usage calls for a robust, standardized and reproducible silk scaffold production and a higher need for silk resources. In this study we standardized the silk fibroin sponges fabrication, set up a quality control protocol, introduced a recycling method to reduce the resources needed and analyzed a sterilization method for translation into preclinical applications. In overall, the development of a fast and efficient quality control protocol led to a reduction in batch-to-batch variabilities. Recycling of silk remnants led to a significant reduction of required silk cocoons of approximately 40 %, with the silk scaffold offering similar product properties as the non-recycled sponges. With the introduction of the recycling trial, we correspond to the requirements for green biomaterials including waste reduction, life cycle introduction and a reduction of environmental impact. Under sterilization conditions, the silk scaffold demonstrated high stability proving that gamma sterilization can be used for bigger batch applications and medical translation. Our establishment of a recycling possibility can pave the way for broader, standardized and "greener" biomedical applications of silk fibroin.