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"Faces" of the day:

Theresa Helena Benezeder

Andrea Renate Teufelberger

Natascha Berger

Bettina Amtmann

Katharina Artinger

Martina Kollmann

Natalie Bordag

Ursula Hiden

Isabella Perchthaler

Regina Roller-Wirnsberger

Johannes Nikolaus Woltsche

Mahmoud Abdellatif

Christoph Suppan

Clemens Painsi

Alexander Mahnert

Amin El-Heliebi

Martin Hönigl

Robert Sucher

Harald Sourij

Simon Sedej

Michael Khalil

Christian Enzinger

Wolfgang Weger

Slave Trajanoski

Philipp Metnitz

Peter Wolf

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Soelva, V; Hernáiz Driever, P; Abbushi, A; Rueckriegel, S; Bruhn, H; Eisner, W; Thomale, UW.
Fronto-cerebellar fiber tractography in pediatric patients following posterior fossa tumor surgery.
Childs Nerv Syst. 2013; 29(4): 597-607. Doi: 10.1007/s00381-012-1973-8
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Sölva Verena

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Abstract:

Fronto-cerebellar association fibers (FCF) are involved in neurocognitive regulatory circuitry. This may also be relevant for cerebellar mutism syndrome (CMS) as a complication following posterior fossa tumor removal in children. In the present study, we investigated FCF by diffusion tensor imaging in affected children and controls. Diffusion-weighted MR imaging at 3 T (GE) allowed tractography of FCF using a fiber tracking algorithm software (Brainlab 2.6) in 29 patients after posterior fossa tumor removal and in 10 healthy peers. Fiber tract volumes were assessed and fiber signals were evaluated in a semiquantitative manner along the anatomical course. Volumes of FCF revealed significant diminished values in pediatric patients with symptoms of CMS (19.3 ± 11.7 cm(3)) when compared with patients without symptoms of CMS (26.9 ± 11.9 cm(3)) and with healthy peers (36.5 ± 13.82 cm(3)). In medulloblastoma patients, the volume of FCF was also significantly reduced in patients with symptoms of CMS despite having the same antitumor therapy. In semiquantitative analysis of the fiber tract signals, differences were observed in the superior cerebellar peduncles and midline cerebellar structures in patients with symptoms of CMS. Using DTI, which allows the visualization of fronto-cerebellar fiber tracts, lower FCF tract volumes and diminished fiber signal intensities at the level of the superior cerebellar peduncles and in midline cerebellar structures were identified in patients with postoperative symptoms of CMS. Our study refers to the role of a neural circuitry between frontal lobes and the cerebellum being involved in neurocognitive impairment after posterior fossa tumor treatment in children.

Find related publications in this database (using NLM MeSH Indexing)

Adolescent -

Cerebellum - pathology Cerebellum - surgery

Child -

Child, Preschool -

Cranial Fossa, Posterior - surgery

Cross-Sectional Studies -

Diffusion Magnetic Resonance Imaging -

Female -

Frontal Lobe - pathology Frontal Lobe - surgery

Humans -

Male -

Medulloblastoma - pathology Medulloblastoma - surgery

Mutism - etiology Mutism - pathology

Neurosurgical Procedures - adverse effects

Skull Base Neoplasms - pathology Skull Base Neoplasms - surgery

Find related publications in this database (Keywords)

Diffusion tensor imaging

Tractography

Pediatric brain tumor

Posterior fossa surgery

Cerebellar mutism

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