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"Faces" of the day:

Theresa Helena Benezeder

Andrea Renate Teufelberger

Natascha Berger

Bettina Amtmann

Katharina Artinger

Martina Kollmann

Natalie Bordag

Ursula Hiden

Isabella Perchthaler

Regina Roller-Wirnsberger

Johannes Nikolaus Woltsche

Mahmoud Abdellatif

Christoph Suppan

Clemens Painsi

Alexander Mahnert

Amin El-Heliebi

Martin Hönigl

Robert Sucher

Harald Sourij

Simon Sedej

Michael Khalil

Christian Enzinger

Wolfgang Weger

Slave Trajanoski

Philipp Metnitz

Peter Wolf

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Filippi, M; Rocca, MA; Barkhof, F; Brück, W; Chen, JT; Comi, G; DeLuca, G; De Stefano, N; Erickson, BJ; Evangelou, N; Fazekas, F; Geurts, JJ; Lucchinetti, C; Miller, DH; Pelletier, D; Popescu, BF; Lassmann, H; Attendees of the Correlation between Pathological MRI findings in MS workshop.
Association between pathological and MRI findings in multiple sclerosis.
Lancet Neurol. 2012; 11(4):349-360 Doi: 10.1016/S1474-4422(12)70003-0
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Fazekas Franz

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Abstract:

The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis (MS). Pathological assessment is the gold standard for such identification, but has intrinsic limitations owing to the limited availability of autopsy and biopsy tissue. MRI has gained a leading role in the assessment of MS because it allows doctors to obtain an ante mortem picture of the degree of CNS involvement. A number of correlative pathological and MRI studies have helped to define in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also in the spinal cord. These studies have resulted in the identification of aspects of pathophysiology that were previously neglected, including grey matter involvement and vascular pathology. Despite these important achievements, numerous open questions still need to be addressed to resolve controversies about how the pathology of MS results in fixed neurological disability. Copyright © 2012 Elsevier Ltd. All rights reserved.

Find related publications in this database (using NLM MeSH Indexing)

Brain - pathology Brain - physiopathology

Humans -

Magnetic Resonance Imaging - classification Magnetic Resonance Imaging - methods

Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology

Optic Nerve - pathology Optic Nerve - physiopathology

Spinal Cord - pathology Spinal Cord - physiopathology

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