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Herak, JN; Pifat, G; Brnjas-Kraljevic, J; Lipka, G; Müller, K; Knipping, G.
Causal relationship between the transitions in the core and the surface in porcine low-density lipoproteins.
Chem Phys Lipids. 1988; 48(1-2):135-139 Doi: 10.1016/0009-3084(88)90141-7
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Abstract:: Two independent parameters, two characteristic temperatures, one indicating the change in the molecular organization of the core, Tc, and the other in the surface layer, Ts, were measured for a number of natural and triglyceride-enriched porcine low-density lipoprotein (LDL1 (buoyant density 1.020--1.063 g/ml) and LDL2 (buoyant density 1.063--1.080 g/ml) samples. Tc was determined by differential scanning calorimetry (DSC), whereas Ts was measured by Mn(II) binding to the lipoprotein surface followed by electron spin resonance (ESR) spectroscopy. A significant causal relationship between Tc and Ts in both LDL subfractions demonstrates the surface-core interaction in LDL. The significance of that interaction is emphasized as a possible link in the chain diet----lipoprotein changes----atherosclerosis.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Calorimetry, Differential Scanning -; Electron Spin Resonance Spectroscopy -; Lipoproteins, LDL - blood; Swine - blood; Temperature - blood; Triglycerides - blood