Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wascher, TC; Graier, WF; Dittrich, P; Hussain, MA; Bahadori, B; Wallner, S; Toplak, H.
Effects of low-dose L-arginine on insulin-mediated vasodilatation and insulin sensitivity.
Eur J Clin Invest. 1997; 27(8):690-695
Doi: 10.1046%2Fj.1365-2362.1997.1730718.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Wascher Thomas
- Co-Autor*innen der Med Uni Graz
- Graier Wolfgang
- Holasek Sandra Johanna
- Toplak Hermann
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- Abstract:
- The present study was carried out to evaluate the effect of a low-dose intravenous supplementation of L-arginine on insulin-mediated vasodilatation and insulin sensitivity. The study was performed in healthy subjects (n = 7) and patients with obesity (n = 9) and non-insulin-dependent diabetes mellitus (NIDDM) (n = 9). Insulin-mediated vasodilatation was measured by venous occlusion plethysmography during the insulin suppression test, evaluating insulin sensitivity. Experiments were performed twice in each subject in the presence or absence of a concomitant infusion of L-arginine (0.52 mg kg-1 min-1). L-Arginine restored the imparied insulin-mediated vasodilatation observed in obesity (22.4 +/- 4.1%, P < 0.01 vs. without L-arginine) and NIDDM (20.3 +/- 3.2%, P < 0.01 vs. without L-arginine). In healthy subjects, no effect on insulin mediated-vasodilatation was observed (24.8 +/- 3.1% vs. 21.4 +/- 3.1%). Insulin sensitivity was improved significantly (P < 0.001) in all three groups by infusion of L-arginine. No effect of L-arginine was observed on insulin, insulin-like growth factor I (IGF-I), free fatty acids (FFAs) or C-peptide levels during the insulin suppression test. Our data indicate that defective insulin-mediated vasodilatation in obesity and NIDDM can be normalized by intravenous L-arginine. Furthermore, L-arginine improves insulin sensitivity in obese patients and NIDDM patients as well as in healthy subjects, indicating a possible mechanism that is different from the restoration of insulin-mediated vasodilatation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Arginine - administration and dosage
- C-Peptide - blood
- Diabetes Mellitus, Type 2 - drug therapy
- Fatty Acids - blood
- Female - blood
- Humans - blood
- Insulin - blood
- Insulin Resistance - blood
- Insulin-Like Growth Factor I - metabolism
- Male - metabolism
- Middle Aged - metabolism
- Obesity - drug therapy
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- L-Arginine
- Insulin-Mediated Vasodilatation
- Insulin Sensitivity
- Endothelial Dysfunction