Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

Lehnert, M; Jakse, R; Seewann, HL.
Drug therapy in advanced squamous cell carcinoma of the ORL region
Onkologie. 1984; 7(5):297-299 Doi: 10.1159/000215464
Web of Science PubMed FullText FullText_MUG

Autor*innen der Med Uni Graz:
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: This paper reviews the role of chemotherapy in advanced squamous cell carcinoma of the head and neck region (SSCHN). Two different areas of administration are discussed separately: (1) Palliative therapy in recurrent disease, and (2) chemotherapy as additional measure in first line treatment of advanced SSCHN aiming at an increase of the disease-free survival and the cure rate. Overall response rates of 80% and complete clinical remissions in about 40% of the cases can be achieved in locally untreated tumors. On the other hand, recurrent SSCHN respond not as well to chemotherapy; nevertheless, a good temporary palliative effect is reached in more than half of the patients. As example for the numerous combination programs studied in the last few years, we report some data of the two protocols evaluated at our clinic, cis-diamminedichloroplatinum/adriamycin and methotrexate/5-fluorouracil, respectively.
Find related publications in this database (using NLM MeSH Indexing): Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Squamous Cell - drug therapy; Cisplatin - administration and dosage; Doxorubicin - administration and dosage; Drug Administration Schedule - administration and dosage; Fluorouracil - administration and dosage; Head and Neck Neoplasms - drug therapy; Humans - drug therapy; Leucovorin - administration and dosage; Methotrexate - administration and dosage; Neoplasm Recurrence, Local - drug therapy; Neoplasm Staging - drug therapy; Palliative Care - drug therapy; Prognosis - drug therapy