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Stark, G; Stark, U; Bachernegg, M; Kasper, K; Kickenweiz, E; Decrinis, M.
A comparison of the effects of adenosine and verapamil on the conduction and pacemaker system of isolated guinea pig hearts.
Clin Cardiol. 1993; 16(12):859-862 Doi: 10.1002/clc.4960161205
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Abstract:: Adenosine and verapamil are effective in the treatment of supraventricular arrhythmias. Also, both substances can provoke sinus node arrest or a third-degree atrioventricular (AV) block with a ventricular escape rhythm. The aim of this study was to compare the effects of adenosine and verapamil on sinus rate and on the rate of the ventricular escape rhythm while a third-degree AV block was induced by both drugs. Experiments were performed on isolated spontaneously beating guinea pig hearts perfused by the method of Langendorff. A third-degree AV block was induced by adenosine at a concentration of 30 microns and by verapamil at a concentration of 1 micron. Adenosine (30 microns) reduced sinus rate only moderately whereas it nearly halved the rate of the ventricular escape rhythm compared with that produced by cutting the AV node. In contrast, verapamil left the rate of the ventricular escape rhythm unchanged but nearly halved the spontaneous sinus rate compared with control conditions. In conclusion, adenosine and verapamil given at dosages with comparable effect on the AV node have markedly different effects on different pacemakers in the same heart. In the treatment of supraventricular arrhythmias, adenosine probably should be used with great caution since it can cause a very slow ventricular escape rhythm.
Find related publications in this database (using NLM MeSH Indexing): Adenosine - adverse effects; Animals - adverse effects; Female - adverse effects; Guinea Pigs - adverse effects; Heart Block - chemically induced; Heart Conduction System - drug effects; Heart Rate - drug effects; Heart Ventricles - drug effects; Male - drug effects; Sinoatrial Node - drug effects; Verapamil - adverse effects
Find related publications in this database (Keywords): Adenosine; Verapamil; Ventricular Escape Rhythm; Sinus Rate; Isolated Heart Preparation