Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schuller-Petrovic, S; Wolzt, M; Böhler, K; Jilma, B; Eichler, HG.
Studies on the effect of short-term oral dihydroergotamine and troxerutin in patients with varicose veins.
CLIN PHARMACOL THER. 1994; 56(4): 452-459.
Doi: 10.1038/clpt.1994.160
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schuller-Petrovic Sanja
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- Abstract:
- OBJECTIVE: To evaluate the clinical efficacy and pharmacologic effects of dihydroergotamine and troxerutin on varicose veins. METHODS: A double-blind, randomized, placebo-controlled parallel-group study was conducted in 53 patients with primary varicose veins. Patients received either a fixed combination of 3 mg dihydroergotamine and 300 mg troxerutin three times a day or placebo for 3 weeks. Symptomatic improvement was assessed by a self-assessment score, venocontracting effects on a varicose vein were quantified by the venous compliance technique (VCT), and changes in venous dysfunction were measured by digital photoplethysmography (DPPG). RESULTS: A significant reduction (p < 0.01) of subjective symptoms was observed in both groups. Results from VCT and DPPG after the therapy with dihydroergotamine and troxerutin or placebo were not significantly different (p > 0.05) from pretreatment values. Furthermore, no significant intergroup difference was observed when the before- and after-therapy differences of values of the self-assessment scores (VCT and DPPG) were compared. CONCLUSION: In our study, 3 weeks of treatment with a fixed drug combination of 3 mg dihydroergotamine plus 300 mg troxerutin three times a day had no measurable effect compared with placebo on any of the evaluated end points.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Dihydroergotamine - administration and dosage
- Double-Blind Method - administration and dosage
- Drug Therapy, Combination - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Hydroxyethylrutoside - administration and dosage
- Male - administration and dosage
- Middle Aged - administration and dosage
- Photoplethysmography - methods
- Time Factors - methods
- Varicose Veins - drug therapy
- Vasoconstrictor Agents - administration and dosage