Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Cserni, G; Zombori, T; Andreu, X; Bianchi, S; Regitnig, P; Amendoeira, I; Balmativola, D; Kovács, A; Cordoba, A; Reiner, A; Kulka, J; Kaya, H; Liepniece-Karele, I; Quinn, C; Kővári, B.
Is Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes?
Pathol Oncol Res. 2018; 24(1):167-170
Doi: 10.1007/s12253-017-0229-z
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- Co-authors Med Uni Graz
- Regitnig Peter
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- Abstract:
- Tumor draining sentinel lymph nodes (SLNs) are the sites of selective changes as compared to non-SLNs. They show features of tumor-reactive lymphadenopathy, including increased total number of functional blood vessels, but a relative immunosuppressed status has also been described in them. We explored the hypothesis of a selective regression or non-regression in SLNs versus non-SLNs in 142 patients with 110 estrogen receptor-positive and 32 estrogen receptor-negative tumors undergoing both SLN biopsy and axillary lymph node dissection after neoadjuvant therapy by assessing the tumoral (metastatic) and regression statuses of SLNs and non-SLNs separately. Of the 89 cases with signs of nodal regression, 22 cases (25%) were in favor of a selective non-regression in SLNs, 18 cases (20%) were supportive of a selective and more pronounced regression in the SLNs and the remaining showed equal degrees of regression or non-regression in SLNs and non-SLNs. The results indicate that there is no obvious difference in the degree of regressive histological changes shown by SLNs and NSLNs. Therefore, this phenomenon may not be a major contributor to the higher false negative rate of SLN biopsy after neoadjuvant treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Axilla -
- Breast Neoplasms - drug therapy
- Breast Neoplasms - pathology
- Breast Neoplasms - surgery
- Female -
- Follow-Up Studies -
- Humans -
- Lymph Node Excision -
- Lymph Nodes - pathology
- Lymph Nodes - surgery
- Middle Aged -
- Neoadjuvant Therapy -
- Prognosis -
- Retrospective Studies -
- Sentinel Lymph Node - pathology
- Sentinel Lymph Node - surgery
- Sentinel Lymph Node Biopsy -
- Find related publications in this database (Keywords)
- Sentinel lymph node
- Non-sentinel lymph node
- Breast cancer
- Neoadjuvant therapy
- Selective regression