Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Költringer, P; Langsteger, W; Lind, P; Pierer, G; Reisecker, F; Eber, O.
Gallopamil and changes of adenosine diphosphate- and collagen-induced thrombocyte aggregation
Arzneimittelforschung. 1991; 41(8):786-788
Web of Science
PubMed
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- Abstract:
- In blood samples of 12 healthy volunteers (5 female, 7 male) the influence of Gallopamil (Procorum, CAS 16662-47-8) on the adenosine-diphosphate- (ADP-) and collagen-induced platelet aggregation was studied. Measurements in platelet rich plasma after induction with 1 mumol ADP and 0.5 microgramml collagen with gallopamil were performed. After incubation mit 250 mumol gallopamil a second test was carried out. The parameters were compared with the U-test. After application of 250 mumol gallopamil a significant reduction of ADP- and collagen-induced platelet aggregation could be observed. This is a sign for a protective effect of gallopamil in atherosclerotic disorders due to its calcium-channel blocking property.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Diphosphate - pharmacology
- Adult - pharmacology
- Collagen - pharmacology
- Female - pharmacology
- Gallopamil - pharmacology
- Humans - pharmacology
- Male - pharmacology
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - pharmacology
- Find related publications in this database (Keywords)
- Calcium Antagonists
- CAS 16662-47-8
- Gallopamil
- Inhibition of Platelet Aggregation
- Clinical Studies
- Platelet Aggregation