Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kahrovic, A; Herkner, H; Werner, P; Angleitner, P; Coti, I; Osipenko, K; Lagler, H; Kocher, A; Ehrlich, M; Zimpfer, D; Andreas, M.
Automated suture securing technology in mitral valve surgery: a strategy to reduce prosthetic dehiscence?
Eur J Cardiothorac Surg. 2026;
Doi: 10.1093/ejcts/ezag013
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- Co-authors Med Uni Graz
- Andreas Martin
- Zimpfer Daniel
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- Abstract:
- OBJECTIVES: This study aimed to assess long-term outcomes of automated titanium fasteners versus hand-tied knots in mitral valve surgery. METHODS: In this retrospective, single-center analysis, 2678 adult patients who underwent mitral valve repair or replacement between November 2008 and November 2024 at the Medical University of Vienna were included. Patients were grouped according to the suture-securing technique used: automated titanium fasteners vs hand-tied knots. The primary end-point was prosthetic dehiscence (either mitral annuloplasty ring or valve replacement prosthesis) requiring reintervention. Secondary end-points comprised ischaemic stroke, intracranial bleeding, and all-cause mortality during the follow-up period. RESULTS: Among the study population, 1072 (40%) underwent mitral valve surgery using an automated titanium fastener device, and 1606 (60%) with conventional hand-tied sutures. A total of 31 patients (1.2%) had prosthetic dehiscence during the follow-up period. The risk of prosthetic dehiscence was significantly lower in the automated titanium fastener group in both univariable (crude sub-hazard ratio 0.32, 95% confidence interval 0.12-0.86, p = 0.023) and multivariable competing risk regression analysis (adjusted sub-hazard ratio 0.34, 95% confidence interval 0.12-0.91, p = 0.033). Automated titanium fastener group was not associated with an increased risk of ischaemic stroke (adjusted sub-hazard ratio 0.92, 95% confidence interval 0.67-1.27, p = 0.600), intracranial bleeding (adjusted sub-hazard ratio 0.89, 95% confidence interval 0.52-1.52, p = 0.675), or all-cause mortality (adjusted hazard ratio 0.93, 95% confidence interval 0.74-1.18, p = 0.559). CONCLUSIONS: The use of an automated titanium fastener device seems to be associated with a lower risk of prosthetic dehiscence in mitral valve surgery. Due to the limited number of prosthetic dehiscence events, and the potential for residual confounding, the results should be interpreted with caution.