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SHR Neuro Cancer Cardio Lipid Metab Microb
Werkl, P; Rademacher, J; Pleyer, U.
HLA-B27 positive anterior uveitis Clinical aspects, diagnostics, interdisciplinary management and treatment
SPEKTRUM AUGENHEILKD. 2025; 39(6): 200-213.
Doi: 10.1007/s00717-025-00604-8
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- Leading authors Med Uni Graz
- Werkl Peter Johannes
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- Abstract:
- Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a separate clinical entity. Young adults between the ages of 20 and 40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.
- Find related publications in this database (Keywords)
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