Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Prunea, DM; Geissler, R; Achim, A; Stark, C; Schnur, SSK; Strobl, B; Bugger, H; Luha, O; Zirngast, B; Schmidt, A; Zirlik, A; Toth, GG.
Long-Term Follow-Up After Direct-Flow Transcatheter Aortic Valve Implantation: A Single Center Experience.
Catheter Cardiovasc Interv. 2025;
Doi: 10.1002/ccd.31647
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Prunea Dan-Mihai
- Toth-Gayor Gabor
- Co-authors Med Uni Graz
- Bugger Heiko Matthias
- Geissler Raffael
- Kanoun Schnur Sadeek Sidney
- Schmidt Albrecht
- Zirlik Andreas
- Zirngast Birgit
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- Abstract:
- AIMS: Valve degeneration after DirectFlow implantation poses a challenge for valve-in-valve procedures due to its fragile polymeric structure and embolization risk. This study analyzes long-term follow-up of patients who underwent TAVI with DF to understand valve degeneration tendencies. METHODS: In this single-center registry, we included all patients who underwent DF implantation in our center. Clinical characteristics and echocardiographic parameters were assessed at baseline and during the latest follow-up. Long-term overall survival was analyzed. Outcome data was compared with a matched cohort of patients who underwent TAVI with other commercial devices during the same period. RESULTS: From 2014 to 2017, 67 patients with significant aortic stenosis were treated with DF; 36 (54%) were male, mean age 83 ± 7 years. Left ventricular ejection fraction was 50 ± 13% with a mean gradient of 46 ± 15 mmHg. Post-procedural echocardiography showed a mean gradient of 16 ± 8 mmHg, markedly higher than the reference group (8 ± 3 mmHg; p < 0.01). This residual gradient showed no progression during follow-up at 20 [9; 39] months (16 ± 9 mmHg; p = 0.52). Overall survival was comparable between DF and the reference group at 12 months (6% vs. 4%, HR 1.37, 95% CI 0.31-6.02) and maximal follow-up of 39 ± 25 months (31% vs. 25%, HR 1.44, 95% CI 0.76-2.73). CONCLUSIONS: According to this single center experience, DF devices resulted in higher residual gradients; however, no signs of faster degeneration or worse long-term outcomes were observed compared to other devices.
- Find related publications in this database (Keywords)
- aortic stenosis
- Direct Flow
- transcatheter aortic valve implantation
- valve degeneration
- valve-in-valve